Neuronavigation Guided iTBS With Personalized Target for Depression

Research on the Efficacy and Brain Network Mechanism of Personalized Targeting Intermittent Theta Burst Stimulation (iTBS) Based on Functional Magnetic Resonance Imaging for the Treatment of Major Depressive Disorder

The study will compare the efficacy of intermittent Theta Burst Stimulation (iTBS) with DLPFC-pgACC personalized target for major depressive disorder (MDD) and explore possible brain network mechanisms. The stimulated targets will be located by magnetic resonance imaging (MRI) based on functional MRI based on functional connectivity respectively. This study aims to identify that functional connectivity targeted iTBS protocols on DLPFC-pgACC personalized target have a better antidepressant efficacy compared the sham group and certify that pgACC is an effective potential effector target.

Inclusion Criteria:

• 18 to 60 years old
• Meet the criteria of the Diagnostic and Statistical Manual of Mental Disorder- V of MDD, single or recurrent
• Meet the threshold on the total HAMD17 score of >17 at both screening and baseline visits
• Able to provide informed consent

Exclusion Criteria:

• any other current or past psychiatric axis-I or axis-II disorders
• severe physical illnesses
• psychotic symptoms, alcohol or drug abuse
• A history of neurological disorders including seizure, cerebral trauma
• MRI evidence of structural brain abnormalities
• Contraindications to MRI and rTMS
• Acute suicide
• Female that is pregnant or breastfeeding