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| Name | Class |
|---|---|
| The Affiliated Hospital of Xuzhou Medical University | OTHER |
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Repetitive transcranial magnetic stimulation (rTMS) is a new neuroelectrophysiological technique developed in recent years. rTMS can affect local and distant cortical function, promote regional reconstruction of cortical function, and has clear curative effect on a variety of neuropsychiatric diseases. Previous study found that rTMS can improve postoperative cognitive function, and there may be a dual biological mechanism. Brain network abnormalities may be the direct cause of postoperative cognitive dysfunction, and neuroinflammation is one of the key molecular mechanisms behind postoperative cognitive dysfunction . rTMS may play a role in the regulation of brain network and inflammatory molecules, and thus play a role in the prevention and treatment of postoperative cognitive dysfunction (POCD).
This study intends to use neuroimaging methods to observe the correlation between neuroinflammation and brain network abnormalities in patients with POCD, and verify the repair effect of rTMS intervention on the pathological changes, so as to provide a theoretical basis for further optimizing the establishment of rTMS localization therapy model for POCD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention group | Experimental | Subjects underwent repetitive transcranial magnetic stimulation for five consecutive days from day 2 to day 6 after surgery. The stimulation target area was the posterior cingulate gyrus, and the neuronavigation system was used to accurately locate the stimulation target in this project. Continuous theta short rapid pulse mode (cTBS) was used. CTBS mode consisted of a slave stimulus delivered every 0.2 seconds (5Hz), and each slave stimulus consisted of three bursts of 50Hz. A single stimulus lasts about 40 seconds and totals 600 pulses. Stimulation sessions are from 8 to 10 a.m. daily. |
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| Control group | Sham Comparator | Subjects underwent repetitive transcranial magnetic stimulation for five consecutive days from day 2 to day 6 after surgery，but the machine does not turn on. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| repetitive transcranial magnetic stimulation | Device | The neural navigation system was used to accurately locate the stimulus target.Continuous theta short rapid pulse mode was used. CTBS mode consisted of a slave stimulus delivered every 0.2 seconds (5Hz), and each slave stimulus consisted of three bursts of 50Hz. A single stimulus lasts about 40 seconds and totals 600 pulses. |
| Measure | Description | Time Frame |
|---|---|---|
| Stroop color words test(SCWT) | The Stroop Color Words test (SCWT) was used to evaluate the dominant inhibition in executive function | Preoperative |
| Trail making test | Trail Making test (TMT) was used to evaluate the set switching in executive function | Preoperative |
| Corsi Block test | The visuospatial working memory of executive function was assessed by the Corsi Block test | Preoperative |
| Stroop color words test(SCWT) | The Stroop Color Words test (SCWT) was used to evaluate the dominant inhibition in executive function | Postoperative 1 week |
| Trail making test | Trail Making test (TMT) was used to evaluate the set switching in executive function | Postoperative 1 week |
| Corsi Block test | The visuospatial working memory of executive function was assessed by the Corsi Block test | Postoperative 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Functional magnetic resonance brain network characteristics | The changes of brain network between intervention group and control group before and after operation were compared. Resting-state fMRI and task-state fMRI were evaluated. | Preoperative |
| Functional magnetic resonance brain network characteristics |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Liwei Wang, Doctor | Contact | +86 18952170255 | doctorlww@sina.com | |
| Yangzi Zhu, Doctor | Contact | +86 18168779150 | zhuyz@188.com |
| Name | Affiliation | Role |
|---|---|---|
| Yangzi Zhu, Doctor | Xuzhou Central Hospital | Principal Investigator |
| Liwei Wang, Doctor | Xuzhou Central Hospital | Study Director |
| Qi Yang, Doctor |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xuzhou Central Hospital | Recruiting | Xuzhou | Jiangsu | 221000 | China |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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| pseudo repetitive transcranial magnetic stimulation | Device | Participant in control group receive pseudo repetitive transcranial magnetic stimulation |
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The changes of brain network between intervention group and control group before and after operation were compared. Resting-state fMRI and task-state fMRI were evaluated. |
| Postoperative 1 week |
| Beijing Chao Yang Hospital |
| Study Director |
| Daqing Ma | Imperial College London, Chelsea and Westminster Hospital | Study Chair |