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This retrospective cohort study aims to investigate the effects of recombinant human growth hormone (rh-GH) on the euploid status of preimplantation blastocysts in AMA patients.
Infertile patients aged 38-46 years old were recruited for study if they fulfill the inclusion criteria and do not have the exclusion criteria.
Treatment group: Women received growth hormone (GH) supplement during antagonist protocol for ovarian stimulation.
Control group: Women received antagonist protocol for ovarian stimulation. The primary outcome is the euploidy rate of blastocysts per stimulation cycle and per testing cycle.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GH group | Experimental | Growth Hormone supplement, GnRH antagonist protocol for ovarian stimulation |
|
| Control group | Active Comparator | No Growth Hormone supplement, GnRH antagonist protocol for ovarian stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Growth hormone | Drug | Growth hormone is supplemented during the ovarian stimulation till the day of trigger |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of cycles which obtained euploid blastocysts | Number of cycles with at least 1 euploid blastocyst divided by the total number of stimulation cycles in a cohort | 1 month after oocyte retrieval |
| Measure | Description | Time Frame |
|---|---|---|
| Euploid blastocyst rate per cohort | Total number of euploid blastocyst in a cohort/total number of biopsied embryos in the same cohort | 1 month after oocyte retrieval |
| Euploidy rate per cycle | Euploidy rate of blastocysts, calculated per stimulation cycle and per testing cycle |
| Measure | Description | Time Frame |
|---|---|---|
| Embryo implantation | Positive serum HCG 14 days after embryo transfer. Implantation rate=number of embryos implanted/embryo of embryos tranferred. | 14 days after embryo transfer |
| Clinical pregnancy | Clinical pregnancy is defined as visualization of the gestational sac on ultrasonography. Clinical pregnancy rate=number of ongoing pregnancies/number of embryos transferred. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Xiaoxi Sun, PhD | Shanghai JIAI Genetics and IVF Institute | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai JIAI Genetics and IVF Institute | Shanghai | Shanghai Municipality | 200011 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37858247 | Derived | Sui Y, Xiao M, Fu J, Li L, Xu Y, Lei C, Sun X. Growth hormone supplementation during ovarian stimulation in women with advanced maternal age undergoing preimplantation genetic testing for Aneuploidy. J Ovarian Res. 2023 Oct 19;16(1):204. doi: 10.1186/s13048-023-01279-y. |
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| ID | Term |
|---|---|
| D013006 | Growth Hormone |
| C092464 | LHRH, Ac-Nal(1)-Cpa(2)-Trp(3)-Arg(6)-Ala(10)- |
| ID | Term |
|---|---|
| D010908 | Pituitary Hormones, Anterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| GnRH antagonist | Drug | GnRH antagonist protocol for ovarian stimulation |
|
| 1 month after oocyte retrieval |
| 30 days after embryo transfer |
| Ongoing pregnancy | Ongoing pregnancy is defined as a viable pregnancy beyond 12 weeks' gestation of the first frozen embryo transfer. Ongoing pregnancy rate=number of ongoing pregnancies/number of embryos transferred. | 12 weeks' gestation |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |