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The purpose of this study is to use MRI images using the OS-CMR technique to view the differences in the hearts of healthy volunteers and participants with a condition called Metabolic Syndrome. The objectives of this project are to compare these two groups and to view how health risks, blood test results, and the time since a Metabolic diagnosis can affect heart health.
Myocardial oxygenation changes during vasoactive breathing maneuvers, observed with oxygenation-sensitive cardiac MRI, will be identified and compared between individuals considered healthy and those fitting the criteria of the Metabolic Syndrome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient Participant | Participants with known Metabolic Syndrome (MetS) |
| |
| Healthy Volunteers | NonS-moking participants with no known pre-existing conditions and who do not take any medications |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac MRI | Diagnostic Test | Participants will undergo an oxygenation-sensitive cardiac MRI and, during the scan, perform a vasoactive breathing maneuver composed of a period of paced hyperventilation followed by a voluntary maximal breath hold. |
| Measure | Description | Time Frame |
|---|---|---|
| Global and segmental Myocardial oxygenation reserve (MORE) | A t-test will be used to assess the difference in global and segmental MORE, at rest, during hyperventilation, and throughout breath hold, between healthy and volunteers and MetS patients. | Baseline |
| Relation between Breathing maneuver induced MORE and known MetS risk factors. | A linear regression will assess the relation between Breathing maneuver induced MORE and known MetS risk factors, biomarkers, and time since diagnosis. | Baseline |
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Inclusion Criteria:
Patient Participants:
Healthy Volunteers:
Exclusion Criteria:
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The study population will be composed of participants with known MetS, based on the identified risk factors, and healthy volunteers.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Katherine Lindsay, Master | Contact | 514-934-1934 | 37305 | katherine.lindsay@mail.mcgill.ca |
| Elizabeth Konidis, Master | Contact | 514-934-1934 | 37305 | elisavet.konidis@muhc.mcgill.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Reseach Institute of the McGill University Health Centre | Recruiting | Montreal | Quebec | H4A 3J1 | Canada |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| D009750 |
| Nutritional and Metabolic Diseases |