Improving Effects of Fish Oil Combined With Pine Bark Extract on Cognitive Decline

The Improving Effects of Fish Oil Supplementation Combined With Pine Bark Extract on Cognition in Aged-related Cognitive Decline

The purpose of this study is to evaluate the improving effects of ω-3 fatty acid from fish oil combined with polyphenolic extract from pine bark (PE) on cognitive functions and biological parameters in healthy people aged 55 to 75.

Sixty participants who meet the inclusion criteria will be randomly divided into two groups. Participants in FO group will be provided one capsule of fish oil (350mg EPA + 250mg DHA) per day for 6 months. Moreover, participants in FOPE group will be provided one capsule of fish oil (350mg EPA + 250mg DHA) combined with PE (100mg Oligopin) per day for 6 months. A cognitive function evaluation, blood biological analysis and antioxidative status will be carried out at the baseline, 3 th month and the end of the supplementation period. On the other hand, blood fatty acid composition will be measured at the baseline and the end of the supplementation period. All participants will come to laboratory and receive the supplements every month. At the same time, they will accept the measurement of body weight and blood pressure, also be interviewed with 24 hours dietary recall questionnaire.

Inclusion Criteria:

• I. 55~75 years old
• II. No severe diseases, such as hyperlipidemia, diabetes, heart diseases, cancer etc.
• III. Mini-mental state examination (MMSE) score is more than 26
• IV. Clinical dementia rating scale (CDRS) score is less than 0.5

Exclusion Criteria:

• liver disease, kidney disease, hypertension, hyperlipidemia, anemia, cancer