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| Name | Class |
|---|---|
| American College of Chest Physicians | OTHER |
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The purpose of this study is to evaluate whether a home rehabilitation program after hospitalization for acute pulmonary embolism (PE) improves clinical outcomes at 3 months compared to usual care. Daily physical activity tasks that incorporate heart rate monitoring will be sent through email or text. This information could help improve the management of acute PE.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants who receive daily activity message | Experimental | The intervention group will receive instructions for a daily activity sent through SMS text message or email. |
|
| Participants who receive control message | Placebo Comparator | The control group will receive daily messages to help with blinding sent through text message or email. The messages will not include activity tasks and will include phrases such as "I hope you have a good day". |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Daily Activity Text | Behavioral | Participants will receive a text each day with instructions about the daily activity they should complete for that day. |
|
| Measure | Description | Time Frame |
|---|---|---|
| mean change in vector magnitude count as measured by actigraphy | The Actigraph triaxial accelerometer will be used to monitor continuous activity at home on the non-dominant wrist. The accelerometer data will be downloaded and will include the vector magnitude count. | 10 weeks |
| mean change in mean amplitude deviation as measured by actigraphy | The Actigraph triaxial accelerometer will be used to monitor continuous activity at home on the non-dominant wrist. The accelerometer data will be downloaded and will include the mean amplitude deviation. | 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| proportion of participants with post-PE syndrome | Participants will be evaluated by a physician to determine if they have post PE-syndrome | 12 weeks |
| mean change in steps as measured by Actigraph |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Lachant, DO | University of Rochester | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Rochester Medical Center | Rochester | New York | 14642 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41662928 | Derived | Roto D, Haight D, Norton K, White RJ, Lachant D. Functional recovery after pulmonary embolism: A pilot study using metabolic monitoring during the 6-minute walk test. Respir Med. 2026 Mar;253:108707. doi: 10.1016/j.rmed.2026.108707. Epub 2026 Feb 7. |
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| ID | Term |
|---|---|
| D011655 | Pulmonary Embolism |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D004617 | Embolism |
| D016769 | Embolism and Thrombosis |
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| Control Text | Behavioral | Participants will receive a text each day with no instructions about daily activity. It will have messages like "have a nice day." |
|
The Actigraph triaxial accelerometer will be used to monitor the number of steps taken at home on the non-dominant wrist. The accelerometer data will be downloaded and will include the step count.
| 12 weeks |
| mean change in activity as measured by Actigraph | The Actigraph triaxial accelerometer will be used to monitor the amount of activity taken at home on the non-dominant wrist. The accelerometer data will be downloaded and will include the amount of activity. | 12 weeks |
| mean change in quality of life as measured by PROMIS | The PROMIS questionnaire ranges from 0-99 with higher scores indicating worse outcome. | 12 weeks |
| mean change in quality of life as measured by Emphasis 10 | The Emphasis 10 questionnaire ranges from 0-50 with higher scores indicating worse quality of life. | 12 weeks |
| mean change in quality of life as measured by Pulmonary Embolism quality of life questionnaire | The pulmonary embolism quality of life questionnaire ranges from 1 to 27 with higher scores indicating worse outcomes. | 12 weeks |
| mean change in 6 minute walking distance | 12 weeks |
| mean change in heart rate during a 6 minute walk | 12 weeks |
| mean change in oxygen use during a 6 minute walk | Oxygen use will be measured by a measured by portable K5 metabolic analyzer. | 12 weeks |
| mean change in carbon dioxide production during a 6 minute walk | Carbon Dioxide use will be measured by a measured by portable K5 metabolic analyzer. | 12 weeks |
| proportion or subjects who develop chronic thromboembolic pulmonary hypertension | 12 weeks |
| D014652 |
| Vascular Diseases |
| D002318 | Cardiovascular Diseases |