LONGitudinal Multi-omics Phenotyping of KIDney Function Alteration

Observation of Alterations in Kidney Function, Immune System and Gut Mircobiota After Living Donor Kidney Transplantation

This is a longitudinal observation of kidney function, immune system and gut microbiota before and 24 weeks after a live kidney transplantation conducted in donor and recipient pairs living in the same household. Outcome measures include kidney function, body composition, blood pressure, gut microbiome composition, metabolomics and immune cell states.

Inclusion Criteria:

• Body-Mass-Index 18,5 - 34,9 kg/m2
• Planned living kidney donation / transplantation

Exclusion Criteria:

• Clinically relevant heart, lung, liver, and kidney diseases
• Postoperative phase
• Acute infections
• Vegan diet
• Change of body weight of more than 10% in the month prior to study entry
• Known drug or alcohol abuse