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Subjective memory complaints (SMC), the main cognitive component of which is event memory, is a predictor of Alzheimer's disease in elderly people. The purpose of this study was to investigate the effect of transcranial alternating current stimulation (tACS) with theta frequency (6 Hz) on the medial prefrontal cortex in the improvement of episodic memory in individuals with SMC in a double blind, randomized, and sham-controlled parallel study. Sixteen participants with SMC received either active or sham theta tACS on the medial prefrontal cortex (mPFC). EEG was recorded and Rey Auditory Verbal Learning Test (RAVLT) was administered. The aim of the current study was to see if theta tACS over the mPFC can improve event memory in individuals with SMC and thus can be considered a potential therapeutic intervention for this population or not.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active tACS | Experimental | Participants in this group received 20 minutes of active 6 Hz stimulation over the medial prefrontal cortex. |
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| Sham tACS | Sham Comparator | Participants in this group received 20 minutes of sham stimulation over the medial prefrontal cortex. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| active tACS | Device | transcranial alternating current stimulation is a non-invasive method of entraining specific frequency bands in the brain by applying weak intensities of electric current in a desired shape and phase to the desired brain regions. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in performance | Rey auditory-verbal learning test (RAVLT) | 25 minutes i.e., before versus after the stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| Change in EEG power in theta frequency band | Spectral analysis measuring power in different frequency bands | 30 minutes, i.e., before versus after stimulation |
| Change in phase synchronization connectivity in theta frequency band |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Reza Rostami, M.D. | University of Tehran | Study Director |
| Sahereh Varastegan, MSc | University of Tehran | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Brain Mapping Lab | Tehran | 1439957131 | Iran |
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| ID | Term |
|---|---|
| D008569 | Memory Disorders |
| ID | Term |
|---|---|
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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| sham tACS | Device | transcranial alternating current stimulation is a non-invasive method of entraining specific frequency bands in the brain by applying weak intensities of electric current in a desired shape and phase to the desired brain regions. |
|
Phase relations between neural signals realized by means of phase-locking values (PLV)
| 30 minutes, i.e., before versus after stimulation |
| D013568 | Pathological Conditions, Signs and Symptoms |