Efficacy of an Antibacterial Toothpaste and Patients' Satisfaction

In Vivo Evaluation of Antibacterial Toothpaste Efficiency and Patients' Satisfaction: a Double-blind Randomised Controlled Trial

The primary objective of this randomized controlled clinical trial (RCCT) will be to compare the efficacy in reducing the quantity of Streptococcus mutans (S. Mutans) in saliva of a recently introduced toothpaste compared to a commercially available toothpaste. The secondary outcomes will be to assess patients' impression of the toothpastes (in terms of taste, satisfaction etc.), and to investigate potential changes in dentin hypersensitivity, plaque formation and gingival inflammation.

Inclusion Criteria:

1. Patients with minimum 20 teeth;
2. Good oral hygiene level (gingival bleeding index not exceeding 20%)
3. Patients willing to participate in the study and able to sign an informed consent

Exclusion Criteria:

1. Tooth anomalies (amelogenesis imperfecta, dentinogenesis imperfecta etc.);
2. Intrinsic stain (fluorosis);
3. Caries lesions;
4. Advanced periodontal disease (probing >2, spontaneous gum bleeding, tooth mobility >1);
5. Smokers;
6. Use of orthodontic devices;
7. Use of antibiotics in the last 3 months;
8. Use of antibacterial mouth rinses in the last 3 months;
9. Potential allergies;
10. Drug and alcohol abuse;