Efficacy and Safety of Cagrilintide s.c. 2.4 Milligram (mg) in Combination With Semaglutide Subcutaneous (s.c). 2.4 mg (CagriSema s.c. 2.4 mg/2.4 mg) Once-weekly in Participants With Overweight or Obesity
Efficacy and Safety of Cagrilintide s.c. 2.4 Milligram (mg) in Combination With Semaglutide Subcutaneous (s.c). 2.4 mg (CagriSema s.c. 2.4 mg/2.4 mg) Once-weekly in Participants With Overweight or Obesity
This study has 2 parts: First part is the main study and second part is the extension study. During the main study participants will receive 1 of 4 study medicines. If participants continue in the extension study, they will not receive any study medicine during the extension. The main study will look at how well CagriSema helps participants with excess body weight lose weight compared to a "dummy" medicine and 2 other medicines, cagrilintide and semaglutide. Participants will either get CagriSema, cagrilintide,semaglutide or "dummy" medicine. Which treatment participants get is decided by chance. They will take one injection once a week. The study medicine is injected briefly with a thin needle, typically in the stomach, thighs or upper arms.
Extension study: After the main study, not all participants will continue in the extension study. The study staff will tell the participant if they will continue or not into the extension study. In the extension study we will look at what happens to the participant's body weight and diseases related to excess body weight after the participant stops taking the study medicine. The main study will last for about 1½ years and the extension study will last for another 2 years.
Inclusion Criteria:
Exclusion Criteria:
- Glycaemia related: a) Glycated Haemoglobin (HbA1c) greater than or equal to 6.5 percent (48 millimoles per mole [mmol/mol]) as measured by the central laboratory at screening b) History of type 1 or type 2 diabetes mellitus
CABA, C1060ABA, Argentina
CABA, C1060ABA, Argentina
CABA, C1120AAC, Argentina
Ciudad de Buenos Aires, C1204AAD, Argentina
Esbjerg, Region Syddanmark 6700, Denmark
Leipzig, 04103, Germany
Chandigarh, Punjab 160012, India
Roma, 00161, Italy
Suita-shi, Osaka 565-0853, Japan
Chiba-shi, Chiba, 260-8677, Japan
Gunma, 373-0036, Japan
Sendai-shi, Miyagi, 983-0039, Japan
Bygdoszcz, Kuyavian-Pomeranian Voivodeship 85-796, Poland
Legnica, Lower Silesian Voivodeship 59-220, Poland
Warsaw, Masovian Voivodeship 00-416, Poland
Poznan, Wielkopolskie Voivodeship 60-198, Poland
Poznan, Wielkopolskie Voivodeship 60-198, Poland
Warsaw, 00-416, Poland
Bucheon-si, Gyeonggi-do 14647, South Korea
Bucheon-si, Gyeonggi-do 14647, South Korea
Seongnam-si, Gyeonggi-do, 13620, South Korea
Adana, 01250, Turkey (Türkiye)
Istanbul, 34390, Turkey (Türkiye)