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We enroll pediatric patients who were diagnosed COVID-19 for main observation target. We will perform brain MRI and neuropsychiatric evaluation 4-6 months after COVID-19 diagnosed. We also enroll healthy age- and gender-matched participant for cross-over comparison. We will perform same evaluation process one year later for longitudinal evaluation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coronavirus disease (COVID) | Pediatric patients who was diagnosed as COVID |
| |
| Healthy | Pediatric participants who hadn't been diagnosed COVID before |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brain MRI | Diagnostic Test | Brain MRI including diffusion spectrum image, and functional MRI Interview with questionnaires for neuropsychiatric evaluation Near infrared spectroscopy and resting-state connectivity evaluation |
| Measure | Description | Time Frame |
|---|---|---|
| Difference between COVID and healthy group | The neuroimage difference between COVID and healthy group and the correlation with neuropsychiatric evaluation | 1 years after enrollment for primary evaluation |
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Inclusion Criteria:
Exclusion Criteria:
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Aged between 6-18 years old pediatric patient diagnosed as COVID would be enrolled. The patient who had neuropsychiatric disorders would be excluded. We also enroll age- and gender-matched healthy participants for cross-over comparison
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wang-Tso Lee, PHD | Contact | (886)2-23123456 | 71618 | leeped@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Wang-Tso Lee, PHD | National Taiwan University Children Hospital Pediatric neurology department | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Children Hospital Pediatric Neurology Department | Recruiting | Taipei | Taiwan |
according to our participant consent, the participant information will be stored as de-identification data
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| ID | Term |
|---|---|
| D000094024 | Post-Acute COVID-19 Syndrome |
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
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| ID | Term |
|---|---|
| D019265 | Spectroscopy, Near-Infrared |
| ID | Term |
|---|---|
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D013057 | Spectrum Analysis |
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Stool
|
| D007239 |
| Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D000094025 | Post-Infectious Disorders |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002623 |
| Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |