Search for BIO Diagnostic and Prognostic Markers in Adult VAScularitis

Search for BIO Diagnostic and Prognostic Markers in Adult VAScularitis

To date, there are no reliable diagnostic blood markers of adult vasculitis. To date, the diagnosis of vasculitis is based on invasive procedure, biopsy of affected tissues potentially at risk of complication . In addition, there are no reliable biomarkers to predict the evolution of vasculitis (relapse, refractory form ...) necessary for the management of patients (type of treatment, duration ..)

Prospective study, monocentric (CHU de Tours), non-interventional, aimed at finding diagnostic and prognostic biomarkers (both metabolomic and immunologic) in adult vasculitis patients.

Specimen will be collected at diagnosis, month 1, month 3, and month12 and at the time of a possible relapse. 14 ml of additional blood during a blood puncture made for routine care will be collected at each visit as well as clinical data.

Inclusion Criteria:

• Age > 16 years
• Active vasculitis, new diagnosis or relapse
• IgA vasculitis
• ANCA vasculitis
• Giant cell arteritis

Exclusion Criteria:

• Person who has objected to the processing of data
• Pregnant woman
• Patient positive for HIV, HBV, HCV
• Treatment in the previous month with corticosteroids, immunosuppressive drugs or biotherapy.
• Patient unable to understand the information leaflet
• Adult under guardianship or curatorship