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This is a prospective, multicentric, european registry of patients with infective endocarditis undergoing cardiac surgery. Patient demographics, clinical data and laboratory values will be collected, as well as treatment outcomes at day 30, day 90 and 1-5 years after the intervention.
Infective endocarditis (IE) is now a relatively rare but worldwide disease (3-10 IE/100000 population/year) with increasing incidence especially in the Western world. IE is still associated with high morbidity and mortality, prolonged hospital stay, high risk of reinfection, significantly worsened prognosis for patients, substantially reduced quality of life, and in any case represents a major financial burden for the respective healthcare systems [1-11].
Patients who need to undergo cardiac surgery due to infective endocarditis (IE) are heterogeneous and present with a persistently high perioperative morbidity and mortality rate. Despite optimal and individualized perioperative management strategies, perioperative complications such as heart failure, systemic inflammatory response, vasoplegia, and sepsis is still the main reason for adverse outcomes following cardiac surgery.
The present European, multicenter IE registry (Surgical RegistRy of infective ENDocarditis in EuRope - SURRENDER) was initiated and established to record and appropriately analyze current surgical treatment options and perioperative adjunctive treatment strategies, as well as short- and long-term patient outcomes.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac surgery | Procedure | Patients with infective endocarditis undergoing open heart surgery |
| Measure | Description | Time Frame |
|---|---|---|
| In-hospital mortality (all cause) | Overall mortality rate in-hospital, at day 30 or during index hospitalization | 30 days or during index hospitalization |
| Mortality at long-term follow-up | at 1 to 5 years post-surgery | 1 to 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| MACCE | Major adverse cardiac and cerebrovascular event rate at day 30 or during index hospitalization. Composite of 1.) Cardiac events: (postoperative myocardial infarction, CPR, LCOS/heart failure, repeat cardiac surgery) and/or cerebrovascular events (postoperative stroke, TIA, intracranial hemorrhage) | 30 days or during index hospitalization |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with infective endocarditis undergoing open heart surgery with cardio-pulmonary bypass
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Matthias Thielmann, Prof. Dr. | Contact | +49-201-723-84908 | matthias.thielmann@uk-essen.de | |
| Wolfgang Ristau | Contact | +49-201-723-84927 | wolfgang.ristau@uk-essen.de |
| Name | Affiliation | Role |
|---|---|---|
| Matthias Thielmann, Prof. Dr. | Department of Thoracic and Cardiovascular Surgery, University Hospital Essen | Principal Investigator |
| Jurij Kalisnik, PD. Dr. | Department of Cardiac Surgery, Hospital Nürnberg, Paracelsus Medical University |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Cardiac Surgery, Hospital Nürnberg, Paracelsus Medical University | Nuremberg | Bavaria | 90471 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32334690 | Background | Thornhill MH, Dayer MJ, Nicholl J, Prendergast BD, Lockhart PB, Baddour LM. An alarming rise in incidence of infective endocarditis in England since 2009: why? Lancet. 2020 Apr 25;395(10233):1325-1327. doi: 10.1016/S0140-6736(20)30530-4. No abstract available. | |
| 29191329 | Background | Olmos C, Vilacosta I, Fernandez-Perez C, Bernal JL, Ferrera C, Garcia-Arribas D, Perez-Garcia CN, San Roman JA, Maroto L, Macaya C, Elola FJ. The Evolving Nature of Infective Endocarditis in Spain: A Population-Based Study (2003 to 2014). J Am Coll Cardiol. 2017 Dec 5;70(22):2795-2804. doi: 10.1016/j.jacc.2017.10.005. |
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| ID | Term |
|---|---|
| D004696 | Endocarditis |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D006348 | Cardiac Surgical Procedures |
| ID | Term |
|---|---|
| D013504 | Cardiovascular Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D019616 | Thoracic Surgical Procedures |
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| MACCE at long term follow-up | Major adverse cardiac and cerebrovascular event rate at 1 to 5 years post-surgery | 1 to 5 years |
| Sepsis accociated mortatilty | Sepsis accociated mortatilty at day 30 or during index hospitalization | 30 days or during index hospitalization |
| Post-operative sepsis | Sepsis at day 30 or during index hospitalization | 30 days or during index hospitalization |
| Vasoactive inotropic score | The sum of maximum dose rates of inotropes and/or vasopressor medications administered the first 72h post-surgery | < 72h post-surgery |
| Mechanical ventilation time | Duration of postoperative invasive/mechanical ventilation post-surgery | 30 days or during index hospitalization |
| Readmission due to IE recurrence | Recurrence of infective endocarditis after 30 days to 1 year post-surgery | 30 days to 1 year post-surgery |
| Renal failure | Occurence of renal failure (KDIGO criteria) | 30 days or during index hospitalization |
| Dialysis (RRT post-surgery) | Occurence of renal failure requiring renal replacement therapy | 30 days or during index hospitalization |
| University Hospital Essen, Department of Thoracic and Cardiovascular Surgery, West-German Heart and Vascular Center, University Duisburg-Essen | Essen | 45122 | Germany |
|
| 31504413 | Background | Habib G, Erba PA, Iung B, Donal E, Cosyns B, Laroche C, Popescu BA, Prendergast B, Tornos P, Sadeghpour A, Oliver L, Vaskelyte JJ, Sow R, Axler O, Maggioni AP, Lancellotti P; EURO-ENDO Investigators. Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study. Eur Heart J. 2019 Oct 14;40(39):3222-3232. doi: 10.1093/eurheartj/ehz620. |
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