Prediction of Non-motor Symptoms in Fully Ambulatory MS Patients Using Vocal Biomarkers

Prediction of Non-motor Symptoms in Fully Ambulatory MS Patients Using Vocal Biomarkers

The investigator will set up a study evaluating vocal biomarkers in people with MS in order to identify persons with non-motor symptoms: depression, cognitive deterioration, and fatigue. Up to now, to the best of the investigator's knowledge, there is no study reporting the use of vocal biomarkers to predict these three non-motor symptoms in people with MS.

Inclusion Criteria:

• Relapsing MS
• Age over 18
• EDSS < 4.0
• Capability of written informed consent

Exclusion Criteria:

• Not fluent in german language
• Relapse or Steroids per os/intra venous < 4 weeks prior to examination
• KM enhancing lesion in MRI < 4 weeks prior to examination
• Other previous disease affecting the speech
• Pregnant patients
• Mental disability and not able to understand the protocol and study tasks in german languagePatients with greater physical and cognitive disability or history of major depressive disorder and suicide attempt/suicidal thoughts
• Patients with sleep disorders and comorbidities associated with extreme fatigue (e.g., fibromyalgia)