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| Name | Class |
|---|---|
| The Royal College of Physicians of Thailand | UNKNOWN |
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This is a prospective randomized placebo-controlled trial to evaluate the efficacy of peppermint oil spraying into the colonic lumen through the scope channel during screening colonoscopy. The primary outcome is to compare the colonic peristalsis between peppermint oil and placebo. The secondary outcomes compare the procedural time, polyp detection rate, adenoma detection rate, and adverse events.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Peppermint oil | Experimental | 1.6% peppermint oil solution 50 ml(Peppermint oil plus simethicone and tween) |
|
| Placebo | Placebo Comparator | Placebo solution 50ml(Simethicone plus tween) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intraluminal peppermint oil | Drug | Intraluminal flushing of peppermint oil solution through the scope channel during the scope withdrawal |
|
| Measure | Description | Time Frame |
|---|---|---|
| Adenoma detection rate(ADR) | Number of adenoma per total participants who were colonoscopy in both groups | During colonoscopy |
| Measure | Description | Time Frame |
|---|---|---|
| Adenoma per posititive participants(APP) | Number of aenama in patients who had found at least one adenoma in both groups | During colonoscopy |
| Colonic peristalsis grading | Percentage of colonic peristalsis grade 0 and 1 in peppermint oil group in both groups |
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Inclusion Criteria:
- Participants with age > 18 years who attended for colorectal cancer screening colonoscopy.
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of internal medicine siriraj hospital, Mahidol university | Bangkok Noi | Bangkok | 10700 | Thailand |
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| ID | Term |
|---|---|
| D003111 | Colonic Polyps |
| ID | Term |
|---|---|
| D007417 | Intestinal Polyps |
| D011127 | Polyps |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Placebo | Drug | Intraluminal flushing of placebo solution through the scope during scope withdrawal |
|
| During colonoscopy |
| Time of polyps resection | Time of polypectomy per polyp in both groups | During colonoscopy |
| Intravenous anti-spasmodic agents | Percentage of intravenous anti-spasmodic agents in both groups | During colonoscopy |
| Adeverse events | Total number of adverse events in both groups | 24 hours after colonoscopy |