Natural History of Duchenne Muscular Dystrophy Cardiomyopathy (DMD-CMP)

Prospective Cardiac Magnetic Resonance Imaging Study in Duchenne Muscular Dystrophy (DMD-CMP)

The purpose of this study is to describe the progression of tissular and functional myocardial abnormalities in patients with Duchenne muscular dystrophy using cardiac magnetic resonance imaging and blood biomarkers assays.

This study is to describe the progression of tissular (late gadolinium enhancement, T1, T2, ECV assessments) and functional (segmental and global contractility, strain) myocardial abnormalities in patients with Duchenne muscular dystrophy using cardiac magnetic resonance imaging and blood biomarkers assays (troponin I, NTproBNP). Comparison between baseline and 2-years assessments will be conducted.

Inclusion Criteria :

• Age >= 6 years
• Genetically proven Duchenne muscular dystrophy
• Affiliation to French medical insurance
• Informed consent provided

Exclusion Criteria :

• Age <6 years
• Left ventricular ejection fraction <30%
• Tracheostomy of hospitalisation for acute respiratory failure <1 year
• Contraindication to MRI: claustrophobia, Gadolinum allergy