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Simultaneous measurement of the three modalities, functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and electroencephalography (EEG) was proven to be feasible and advantageous in evaluating brain structural and functional (via fMRI), metabolic (via PET) and electrophysiological (via EEG) signatures simultaneously under the same conditions. Investigators use trimodal PET-fMRI-EEG imaging to explore the characteristics of brain network damage in patients with disorders of consciousness(DOC), assess the trajectory of consciousness recovery in a prospective observational cohort study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| coma |
| ||
| VS/UWS |
| ||
| MCS |
| ||
| EMCS |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PET-fMRI-EEG | Other | Participants perform PET, fMRI, and EEG simultaneously using a MRI compatible EEG cap |
|
| Measure | Description | Time Frame |
|---|---|---|
| CRS-R total score | The coma recovery scale-revised(CRS-R) total score is used to measure level of consciousness of disorder in enrolled patients. CRS-R consists of six subscales addressing auditory, visual, motor, verbal, communication, and arousal functions.The lowest item on each subscale represents reflexive activity and the highest item represents cognitively mediated behavior. Maximum scores of each subscale are summed to obtain the total score (from 0 to 23).The score for each subscale is based on the presence or absence of a specific behavioral response to a sensory stimulus (higher scores are better). | Patients in coma after 3 weeks enrolled |
| GOSE score | Glasgow Outcome Scale-Extended(GOSE) score is used to measure the functional limitations of participants. GOSE is a 1-8 point scale (1 = Death, 2 = Vegetative State, 3 = Lower Severe Disability, 4 = Upper Severe Disability, 5 = Lower Moderate Disability, 6 = Upper Moderate Disability, 7 = Lower Good Recovery, and 8 = Upper Good Recovery). Patients with higher scores are more independent. | Patients are followed up for 6 months after enrolled |
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Inclusion Criteria:
Exclusion Criteria:
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Participants are selected in patients hospitalised in neurology department of Xijing hospital
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rong Chen | Contact | 18292575563 | cmuchenrong@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Wen Jiang | Xijing Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xijing hospital | Recruiting | Xi'an | Shaanxi | 710032 | China |
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| ID | Term |
|---|---|
| D003244 | Consciousness Disorders |
| D003128 | Coma |
| D018458 | Persistent Vegetative State |
| ID | Term |
|---|---|
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D014474 | Unconsciousness |
| D001925 | Brain Damage, Chronic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |