Postoperative pain status of patients who underwent elective laparoscopic cholecystectomy.

Subject Researched:

Postoperative pain is a result of the inflammatory response to surgical trauma. Local inflammatory mediator response triggered by surgical incision, dissection, retraction, etc. causes an increase in nociceptor sensitivity and hyperalgesia, resulting in the perception of postoperative pain. With the acute phase response caused by surgical trauma, tissue damage is brought under control, infection is limited and the healing process begins. During the inflammatory response, the level of leukocytes in the blood also changes. Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR) and Systemic immune inflammation score (SII) are inexpensive and easily accessible biomarkers calculated from routine hemogram parameters and shown to be helpful in disease investigations and evaluation of treatment response. In this study, the relationship between biomarkers and postoperative pain status due to surgery will be investigated

Inclusion Criteria:

1. Patients aged 18-75 years who underwent elective laparoscopic cholecystectomy.
2. Patients with ASA status1-2-3

Exclusion Criteria:

1. Emergency operated patients
2. Patients switched to open surgery
3. Patients allergic to tramadol
4. Those allergic to paracetamol
5. Those allergic to tenoxicam
6. Patients who cannot use the patient-controlled analgesia device
7. Those with hematological disorders
8. Those receiving immunosuppressive therapy
9. Those with inflammatory disease
10. Those with gastrointestinal tumors
11. Those with rheumatic disease
12. Those with uncontrolled diabetes
13. Those with chronic organ failure
14. Those who use corticosteroids
15. Opioid users
16. Those who have recently had an attack of cholecystitis, pancreatitis

Patients who have undergone elective laparoscopic cholecystectomy

individual participant data will not be shared