Feasibility of Constant Work Rate Testing to Detect Exercise-induced Laryngeal Obstruction

Feasibility of Constant Work Rate Testing to Detect Exercise-induced Laryngeal Obstruction

TITLE Feasibility of constant work rate testing to detect exercise-induced laryngeal obstruction

DESIGN Prospective observational pilot study

AIMS To investigate if constant work rate testing at different work rates will sufficiently induce detectable exercise-induced laryngeal obstruction (EILO) using CLE.

POPULATION Adult patients with EILO

DURATION 01.09.2022 - 30.06.2023

Inclusion Criteria:

• Participant is willing and able to give informed consent for participation in the study.
• Male or Female, aged 18 or above with a clinical suspicion of having EILO.
• Individuals with concurrent asthma can participate in the study provided that their asthma is well-controlled, determined by a negative bronchoprovocation test.

Exclusion Criteria:

• No EILO found in Clinical standard-of-care CLE test
• Not able to complete the exercise test for other reasons than breathlessness or leg fatigue (e.g. injury, disease or disability preventing cycling to maximal exertion).
• Comorbidities other than asthma, which, judged by the investigator, might confound the test results or pose a medical risk to the patient (e.g. cardiac disease, exercise-induced anaphylaxis).
• Current smokers (< 6 months of stopping) or individuals with a significant smoking history (>10 pack years).
• Pregnancy.