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| ID | Type | Description | Link |
|---|---|---|---|
| AAC21-SPA-04 | Other Grant/Funding Number | The French Institute for Public Health Research & The French National Cancer Institute | |
| 2021-A00242-39 | Other Identifier | French Agency for the Safety of Health Products (ANSM) | |
| 21.02.14.82513 | Other Identifier | Research Ethic Committee (CPP) - Sud Méditerranée V |
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| Name | Class |
|---|---|
| ICube Laboratory - Team IGG | UNKNOWN |
| Ithaque Association | UNKNOWN |
| University Hospitals of Strasbourg | UNKNOWN |
| University Hospital, Strasbourg, France |
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Our study main objective is to test whether virtual reality exposure could elicit cocaine craving and its physiological arousal in cocaine users. Investigators aim to compare self-reported cocaine craving, self-efficacy to cope with craving and emotional states levels in 11 voluntary and adults cocaine users in 3 consecutive 10-mins conditions: Neutral VR (virtual reality exposure to neutral stimuli), Cocaine VR (virtual reality exposure to cocaine use-related stimuli) and Relaxation (respiratory relaxation).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Neutral VR | Sham Comparator | Ten minutes virtual reality exposure to neutral stimuli (e.g. neutral picture frames) |
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| Cocaine VR | Experimental | Ten minutes virtual reality exposure to cocaine use-related stimuli (i.e. peers using cocaine, cocaine paraphernalia, cocaine use preparing, cocaine use, etc.) |
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| Relaxation | Other | Ten minutes respiratory relaxation (eyes closed and sitted on a chair) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Virtual Reality Exposure to Neutral Cues | Device | Virtual reality exposure to neutral stimuli (360 degrees visual and audio immersion with Oculus Quest 2 virtual reality headset). Participants stay sitted on chair and can tilt, rotate and move forward and backward upper body members. No interaction with the investigator during the virtual reality immersion. |
| Measure | Description | Time Frame |
|---|---|---|
| Cocaine Craving Intensity | Change in self-reported cocaine craving intensity between 3 consecutive interventions: Neutral VR, Cocaine VR and Relaxation (CCQ-Brief total score, french version; Karila and al., 2011). CCQ-Brief total score varies from 10 to 70 (higher score suggesting higher craving intensity). | Immediatly after Neutral VR, Cocaine VR and Relaxation (10 mins between each measure) |
| Measure | Description | Time Frame |
|---|---|---|
| Self-Efficacy to Cope with Cocaine Craving without Using | Change in self-reported efficacy level to cope with cocaine craving without using between 3 consecutive interventions: Neutral VR, Cocaine VR and Relaxation (DTCQ-8 total score, original version translated in french; Sklar and Turner, 1999). DTCQ-8 total score varies from 0 to 800 (higher score suggesting higher self-efficacy to cope with cocaine craving without using). |
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Inclusion Criteria:
- Cocaine use within the past 28 days
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Thomas Lehoux, Ph.D. Candidate | Laboratoire de Psychologie des Cognitions (Strasbourg University) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Laboratoire de Psychologie des Cognitions (Strasbourg University) | Strasbourg | Bas-Rhin | 67000 | France |
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| OTHER |
| National Cancer Institute, France | OTHER_GOV |
| The French Institute for Public Health Research | UNKNOWN |
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| Respiratory Relaxation | Behavioral | Respiratory relaxation practise. No interaction with the investigator during the relaxation practise. |
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| Virtual Reality Exposure to Cocaine-Related Cues | Device | Virtual reality exposure to cocaine-related stimuli (360 degrees visual and audio immersion with Oculus Quest 2 virtual reality headset). Participants stay sitted on chair and can tilt, rotate and move forward and backward upper body members. No interaction with the investigator during the virtual reality immersion. |
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| Immediatly after Neutral VR, Cocaine VR and Relaxation (10 mins between each measure) |
| Negative Emotional States | Change in negative emotional states level between 3 consecutive interventions: Neutral VR, Cocaine VR and Relaxation (BMIS negative emotional states total score, adapted version translated in french Mayer et al., 1988). BMIS negative emotional states total score varies from 0 to 21 (higher score suggesting higher negative emotional states). | Immediatly after Neutral VR, Cocaine VR and Relaxation (10 mins between each measure) |
| Positive Emotional States | Change in positive emotinal states level between 3 consecutive interventions: Neutral VR, Cocaine VR and Relaxation (BMIS positive emotional states total score, adapted version translated in french Mayer et al., 1988). BMIS positive emotional states total score varies from 0 to 9 (higher score suggesting higher positive emotional states). | Immediatly after Neutral VR, Cocaine VR and Relaxation (10 mins between each measure) |