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The aim of the study is to assess the efficacy of this new ambulatory service model in reducing heart failure hospitalization (HHF), improving clinical as well as functional outcomes of post-discharge patients with Heart Failure of reduced ejection fraction (HFrEF) and Heart failure with preserved Ejection Fraction (HFpEF).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| REDUCE | Standard care |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard care | Other | Standard clinical care |
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical outcome | A composite of all-cause mortality, number of heart failure events (including hospitalization for heart failure (HHF), urgent heart failure visits and unplanned outpatient visits), time to first heart failure event will be aggregated to evaluate overall clinical outcome | 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Kansas City Cardiomyopathy Questionnaire Total Symptom Score (KCCQ-TSS) | Change from baseline in KCCQ-TSS, higher score reflects better outcome, Maximum score 100. | 1 year |
| NT-proBNP level | Change from baseline in NT-proBNP level |
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Inclusion Criteria:
Exclusion Criteria:
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Patient with heart failure with preserved ejection fraction (HFpEF, EF > 50%) and heart failure with reduced ejection fraction (HFrEF, EF <50%)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Daniel Xu | Contact | 35051518 | danielxu@cuhk.edu.hk |
| Name | Affiliation | Role |
|---|---|---|
| Bryan Yan | Chinese University of Hong Kong | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Chinese University of Hong Kong | Shatin | 999077 | Hong Kong |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D059039 | Standard of Care |
| ID | Term |
|---|---|
| D019984 | Quality Indicators, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |
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| 1 year |
| Risk of Heart failure | Change in NYHA class, ELAN-HF score, and MAGGIC Risk score. and Seattle Heart Failure Model Risk Prediction | 1 year |
| Change in overall Cardiac function | Evaluated by left ventricular ejection fraction (LVEF), left ventricle volume index, global longitudinal strain (GLS), E/E' ratio, left atrial (LA) volume index and LA GLS, inferior vena cava (IVC) size, right ventricular systolic pressure (RVSP) and functional mitral regurgitation (MR) will be aggregated to represent the overall cardiac function | 90 days |
| Major Adverse Cardiovascular Event | Time to first occurrence of cardiovascular death or heart failure event | 1 year |
| Hypertensive heart failure (HHF) | Occurrence of HHF | 90 days after initial hospital discharge |
| Quality adjusted Life years gained | Cost effectiveness of ambulatory heart failure service for heart failure events avoided and quality adjusted life years (QALY) gained. | 1 year |
| Change in 6 minute hall walk (6MHW) | Change in 6 minute hall walk (6MHW) result compared with baseline | 90 days |