Correlation Between LR-ACT and Anti Xa Activity During Endovascular Surgery Procedures. AXAES (Anti Xa vs ACT-LR in Endovascular Surgery)

Correlation Between LR-ACT and Anti Xa Activity During Endovascular Surgery Procedures.

Activated clotting time (ACT) is currently recommended to monitor high concentrations heparin anticoagulation. ACT-LR was specifically designed to measure the activity of low dose of heparin used during endovascular surgery. The correlation between ACT-LR and Anti Xa activity which is considered as the gold standard seems to be debated.

Few studies in literature had shown controversial results. These studies were conducted in patients who underwent open as endovascular surgery. However, the ACT monitoring is not recommended in open surgery. In addition, heparin administration protocols are not described and specific to each centre.

In this study investigators want to study the correlation between LR-ACT and anti Xa after introducing a heparin protocol during complex endovascular procedures.

Inclusion Criteria:

• Age ≥ 18 ans
• Weight ≥ 37,5 kg
• Patients operated for
• complex endovascular aortic aneurysm repair
• deep vein recanalization
• complex arterial revascularization (TASC D lesions)
• Patient informed of the study details and who didn't opposed to participate in this research

Exclusion Criteria:

• Known allergy to heparin
• Known hepatic insufficiency with repercussion on coagulation
• Thrombocytopenia
• Known hemostasis disorders
• Anemia defined HB<8 g/L
• Pregnant women
• Persons deprived of their liberty by a judicial or administrative decision
• Persons subject to psychiatric care
• Persons admitted to a health or social establishment for purposes other than research
• Adults subject to a legal protection measure (guardianship, curatorship)