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This study aims to observe inflammatory biomarkers and their trend over the history of the disease in patients suffering from MPN Ph negative; it also wants to identify any correlations between the aforementioned biomarkers and disease outcomes, considering first of all the occurrence of thrombo-haemorrhagic events and the evolution in the accelerated / blast phase of the disease, shedding light on new tools that can potentially guarantee a prompt and better risk stratification
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| Measure | Description | Time Frame |
|---|---|---|
| CBC with leukocyte formula and calculation of the NLR and PLR ratio | 60 months | |
| Occurrence of arterial and venous thrombotic events | type of event, time to event after diagnosis, during illness | 60 months |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of new and conventional inflammatory biomarkers | at the occurrence of the transformation in the overt phase from pre-fibrotic phase in the setting of myelofibrosis or at the occurrence of the evolution of the MPN Ph negative disease in an accelerated and / or leukemic phase or after 6 months from the introduction of conventional cytoreduction or target-therapy ( JAk2 inhibitors) or 6 months after the introduction of inflammatory drugs (iron chelators) |
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Inclusion Criteria:
Exclusion Criteria:
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Adults diagnosed with PV, ET, PMF or post PV and post ET MF, according to current WHO or IWG-MRT criteria (diagnosis since 2000)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elena Maria Elli | Contact | 0392339859 | elena.elli@libero.it | |
| Benedetta Valeri | Contact | benedettavalerihsg@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Azienda Ospedaliera Universitaria Consorziale Policlinico | Recruiting | Bari | Italy |
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| 60 months |
| Time to thrombo-haemorrhagic events | 60 months |
| Time to death and been alive at the end of the study | 60 months |
| Time to evolution of the PH negative MPN disease into the fibrotic, accelerated or leukemic phase | 60 months |
| Policlinico Sant'Orsola Malpighi | Recruiting | Bologna | Italy |
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| ASST Spedali Civili di Brescia | Recruiting | Brescia | Italy |
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| Policlinico Vittorio Emanuele | Recruiting | Catania | Italy |
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| Ospedale Universitario Federico II | Recruiting | Naples | Italy |
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| Policlinico Umberto I, Università La Sapienza | Recruiting | Roma | Italy |
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| Azienda Ospedaliera Universitaria Città della Salute e delle Scienza | Recruiting | Torino | Italy |
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| Ospedale San Luigi di Orbassano - Ospedale Mauriziano | Recruiting | Torino | Italy |
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| Azienda Ospedaliera Universitaria Friuli Centrale | Recruiting | Udine | Italy |
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| Azienda Ospedaliera Universitaria Integrata | Recruiting | Verona | Italy |
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| Ospedale Belcolle | Recruiting | Viterbo | Italy |
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| ID | Term |
|---|---|
| D009196 | Myeloproliferative Disorders |
| ID | Term |
|---|---|
| D001855 | Bone Marrow Diseases |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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