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Reintubation after failed extubation would be associated with increased mortality. Therefore, extubation failure remains a major concern in ICU. Few randomized controlled studies have assessed the benefit for a systematic respiratory support (noninvasive ventilation or high flow nasal cannula) applied at the time of extubation to reduce reintubation rates in patients at high and low risk for reintubation. In addition, these studies reported discordant results. Therefore, there are some concerns regarding effectiveness and systematic uptake of a respiratory support after extubation into usual practice.
The aim of this trial is to determine whether a protocolized postextubation respiratory support including High-flow Nasal Oxygen (HFNO) and Noninvasive Ventilation (NIV) could reduce the rate of reintubation in comparison with usual practice. Therefore, all consecutively eligible patients for the study, will be assigned to a protocol arm in accordance with the randomized period
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control period | No Intervention | the control period corresponds to usual care of centers | |
| protocolized period | Experimental | the protocolized period corresponds to a protocolized use of HFNO or NIV after extubation |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| protocolized postextubation support | Procedure | The intervention corresponds to a protocolized use of HFNO or NIV after extubation in accordance with the risk of extubation failure: a) 24H HFNO in patient at low risk of extubation failure b) 48H NIV+/-HFNO in patients at high risk of extubation failure |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of reintubation | Reintubation following extubation | 7 days following extubation |
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Inclusion Criteria:
Exclusion Criteria:
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A stepped wedge cluster randomized trial
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