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Sub-study of the main Pulmonary Fibrosis Biomarker (PFBIO) cohort (NCT02755441), recruiting patients with an MDT-diagnosis of hypersensitivity pneumonitis (HP). Patients are included for the collection of blood samples and regular clinical data.
The database and biobank will be available for studies of HP, and can be directly compared to the main PFBIO cohort, which has recruited patients with Idiopathic pulmonary Fibrosis (IPF) since 2016.
Biomarkers will be assessed as diagnostic and prognostic. Further subtyping of HP, based on blood markers (including precipitins) will also be possible with the PFBIO-HP project.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with an MDT-diagnosis of hypersensitivity pneumonitis (HP) | The overall inclusion criteria of patients in the HP cohort are:
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| Measure | Description | Time Frame |
|---|---|---|
| Diagnosis of HP | MDT-Diagnosis of HP | 0 days |
| Exposure to inciting antigen (patient reported) | Known exposure, as reported by the patient | 0 days |
| Exposure to inciting antigen (measurable) | Measurable exposure, as tested by precipitins | 0 days |
| Progression free survival | Survival without progression | 3 years |
| Overall survival | Survival after diagnosis | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of life questionnaires | SGRQ | 3 years |
| Pulmonary function test | FVC | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
- Unable to sign informed consent
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All adult patients with an MDT-diagnosis of HP are eligible.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nils Hoyer, PhD | Contact | +45-3867 4200 | nils.hoyer@regionh.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of respiratory medicine | Recruiting | Hellerup | Copenhagen | 2900 | Denmark |
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| ID | Term |
|---|---|
| D000542 | Alveolitis, Extrinsic Allergic |
| D004194 | Disease |
| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012130 | Respiratory Hypersensitivity |
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There will be collected serum, EDTA plasma and DNA from included subjects.
| Pulmonary function test | DLCO | 3 years |
| Imaging | HRCT scans | 3 years |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |