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The purpose of this study was to asses differences in nycthemeral (24-h) intraocular pressure (IOP) profiles and outflow facilities between patients who have undergone epibulbar microshunt implantation and ab interno trabeculectomy, respectively.
Recent studies involving continuous, 24-hour intraocular pressure (IOP) monitoring in glaucoma patients linked IOP variation to disease progression.
No study has previously compared the postoperative IOP variation of microshunt (Preserflo, P) implantation to ab interno trabeculectomy (Trabectome, T).
In this prospective cohort, the investigators analyzed 68 patients (34 P and 34 T) who presented for 24-hour IOP monitoring 6 to 12 months after surgery. Surgery must have been conducted between October 2020 and July 2021. Patients were assigned to each study group according to the intervention undergone, P or T. IOP and tonographic outflow facility were measured in the habitual position using a pneumatonometer. The IOP variation was considered the primary outcome measure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Microshunt patients | Experimental | Pneumatonometry of the intraocular pressure was performed on patients who have undergone previous microshunt implantation. |
|
| Ab interno trabeculectomy patientes | Experimental | Pneumatonometry of the intraocular pressure was performed on patients who have undergone previous ab interno trabeculectomy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pneumatonometry after microshunt implantation | Diagnostic Test | Pneumatonometry was perfomed over 24 hours at 5 point in time (5 AM, 11 AM, 4 PM, 8 PM, and midnight) using a Pneumatonometer. The measurement was conducted in the habitual position. |
| Measure | Description | Time Frame |
|---|---|---|
| Intraocular pressure variation | 24-hour variation in intraocular pressure obtained by the use of a pneumatonometer. | Obtained 6-12 months after patients have undergone microshunt implantation and ab interno trabeculectomy, respectively. Measurements were taken at 5 points in time over 24 hours (at 5 AM, 11 AM, 4 PM, 8 PM, and midnight). |
| Measure | Description | Time Frame |
|---|---|---|
| Outflow facility | Outflow facility of the aqueous humor from the eye obtained by pneumatonography. | Obtained 6-12 months after patients have undergone microshunt implantation and ab interno trabeculectomy, respectively. Measurements were taken at 5 points in time over 24 hours (at 5 AM, 11 AM, 4 PM, 8 PM, and midnight). |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Ophthalmology University Hospital Wuerzburg | Würzburg | Bavaria | 97070 | Germany |
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| Label | URL |
|---|---|
| Deployed Pneumatonometer Device | View source |
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| ID | Term |
|---|---|
| D005901 | Glaucoma |
| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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| Pneumatonometry after ab interno trabeculectomy | Diagnostic Test | Pneumatonometry was perfomed over 24 hours at 5 point in time (5 AM, 11 AM, 4 PM, 8 PM, and midnight) using a Pneumatonometer. The measurement was conducted in the habitual position. |
|
| Intraocular pressure |
Intraocular pressure obtained by the use of a Pneumatonometer |
| Obtained 6-12 months after patients have undergone microshunt implantation and ab interno trabeculectomy, respectively. Measurements were taken at 5 points in time over 24 hours (at 5 AM, 11 AM, 4 PM, 8 PM, and midnight). |