We design this randomized controlled trial to explore the safety and efficacy of the long-term-opioid-free anesthesia in anterior cervical surgery, to reduce the dosage of perioperative long-acting opioids and promoting patients'rehabilitation.

Inclusion Criteria:

• Patients undergoing anterior cervical surgery., sign the "informed consent form"
• Age above 18 years old
• ASA Ⅰ-Ⅲ.

Exclusion Criteria:

• Pregnant or lactating women.
• Patients with history of drug abuse, including but not limited to opioids, amphetamines, ketamine, etc
• Allergic to the materials or drugs used in this study.
• Patients with current/previous gastrointestinal bleeding and gastric ulcers;
• Have history of nervous system diseases such as peripheral neuropathy, or psychiatric mental illness.
• Other conditions that the investigators consider unsuitable for participation in the study, such as deaf, Parkinson's disease, and difficult to communication etc.