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Evaluation of immune persistence after rabies vaccination in 150 people.
150 subjects aged 10-60 were recruited to inoculate the frozen human rabies vaccine (Vero cells) produced and marketed by Changchun Zhuoyi Biological Co., Ltd. in the whole process of 0, 3, 7, 14 and 28 day immunization. The immunogenicity persistence and safety of the test vaccine were evaluated 14 days, 6 months and 12 months after the whole process of vaccination.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| experimental arm | Experimental | 5 doses of rabies vaccine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 5 doses program | Biological | Inoculate 5 doses of rabies vaccine, and collect blood at fixed time points to detect neutralizing antibody |
|
| Measure | Description | Time Frame |
|---|---|---|
| positive conversion rate evaluation (6 months) | Evaluate the positive conversion rate 6 months after vaccination of rabies vaccine according to the 5-dose immunization program | 6 months |
| antibody titer evaluation (6 months) | Evaluate the antibody titer of serum neutralizing antibody 6 months after vaccination of rabies vaccine according to the 5-dose immunization program | 6 months |
| positive conversion rate evaluation (12 months) | Evaluate the positive conversion rate 12 months after vaccination of rabies vaccine according to the 5-dose immunization program | 12 months |
| antibody titer evaluation (12 months) | Evaluate the antibody titer of serum neutralizing antibody 12 months after vaccination of rabies vaccine according to the 5-dose immunization program | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Li Miao, Dr | Changchun Zhuoyi Biological Co., Ltd | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Changchun Zhuoyi Biological Co., Ltd | Changchun | Jilin | 130000 | China |
all data of antibody titer .
before December 2022.
public for all.
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| ID | Term |
|---|---|
| D011818 | Rabies |
| ID | Term |
|---|---|
| D018353 | Rhabdoviridae Infections |
| D018701 | Mononegavirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
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| D007239 | Infections |