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sub gingival application of hyaluronic acid create great clinical improvement of periodontal pocket treatment.
To clinically and radiographically evaluate the adjunctive effect of the local application of a 0.8% hyaluronan gel in addition to scaling and root planing in treatment of controlled diabetic patients with stage II periodontitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hyaluronic acid | Experimental | Application of crosslinked HA gel in pockets after subgingival debridement immediately and one week after. |
|
| scaling and root planing | Active Comparator | scaling and root planing using ultrasonic scaler and hand instruments. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hyaluronic acid | Drug | anti-inflammatory, anti-edematous, osseoinductive. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical attachment level gain | Clinical attachment gain by using UNC15 Periodontal probe/ numerical data | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Pocket depth reduction | Pocket depth reduction by using UNC15 Periodontal probe/ numerical data | 3 moths |
| Bleeding on probing | Bleeding on probing by using UNC15 Periodontal probe/ binary data |
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Inclusion Criteria:
Exclusion Criteria:
• The use of antibiotics or anti-inflammatory drugs 1 month prior to the procedure and till the end of 6 months of follow-up.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Reem M Alabbadi, BDS | Contact | 00201551563633 | reem.alabbadi@dentistry.cu.edu.eg | |
| Nesma M Shemais, PHD | Contact | 00201005615697 | nesma.shemais@dentistry.cu.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Reem M Alabbadi, BDS | master student | Principal Investigator |
| Nesma M Shemais, PHD | Lecturer of Oral Medicine and Periodontology- faculty of dentistry/Cairo University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| faculty of dentistry Cairo university | Recruiting | Cairo | 12311 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40665270 | Derived | Al-Abbadi R, Shemais N, Nawwar A, Fawzy El-Sayed KM. Non-surgical periodontal therapy with and without hyaluronic acid gel in type 2 diabetic stage-II periodontitis patients: a randomized clinical trial. BMC Oral Health. 2025 Jul 15;25(1):1166. doi: 10.1186/s12903-025-06485-2. |
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| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D006820 | Hyaluronic Acid |
| ID | Term |
|---|---|
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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| 3 months |
| Gingival Recession | Gingival Recession by using UNC15 Periodontal probe/ numerical data | 3 months |
| Radiographic Evaluation | by using periapical radiograph with standardized acrylic stent | 3 months |
| Karim F Elsayed, professor |
| Associate Professor of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University |
| Study Chair |