T-mult is an experimental study using low-frequency (1Hz) single-sesson rTMS to the DLPFC (versus sham rTMS) to explore the effect of virtual lesions on the brain network and cognition in 100 healthy adults (20-65 years old).

Inclusion Criteria:

• Age between 20 and 65 years old
• Native Dutch speaker
• Able to provide written informed consent

Exclusion Criteria:

• History of diagnosed neurological or psychiatric disease (including traumatic head injury)
• Current and regular use of centrally acting drugs (recreational or prescribed, including analgesics), including the use of alcohol ~8 hours prior to an appointment
• Presence of any contraindications for MRI, MEG, or TMS (including resting motor threshold >75% of maximum stimulator output or no useful motor-evoked potential elicitable)
• Previous rTMS treatment

In the pursuit of open science, we intend to make this dataset available to a larger part of the scientific community. Participants will be asked for their permission to do so in the Informed Consent form; if permission is given we will, upon completion of the study, upload coded data that has been scrubbed of all PHI (i.e. clear all PHI in the header information, deface MR images) to DANS (Data Archiving and Networked Services, www.dans.knaw.nl), a Dutch repository for research data. DANS allows for the use of a "restricted access" license for the reuse of data that ensures anyone who wishes to use the data acts in accordance with applicable local laws and regulations (e.g. AVG).

Note that participants who are unwilling to provide permission to share their data will still be included in this study (their data will then not be uploaded to DANS).

Upon completion of the study

See plan description