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The investigators will collect biosamples of patient blood and tumour tissue for further immunological analysis of blood cell subpopulations, immunosupressive factors concentration, HLA expression an lymphocytes and tumour tissue, and and cancer testis antigenes expression on tumour cells, as well as clinical data on patient's stage, therapy, response and demographics. Possible prognostic and predictive dynamic biomarkers will be discovered for individualisation of treatment strategies
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Melanoma | |||
| Soft tissue sarcoma | |||
| Kidney cancer | |||
| Primary brain tumors | |||
| Malignant neoplasms | |||
| Prostate cancer | |||
| Colorectal cancer |
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| Measure | Description | Time Frame |
|---|---|---|
| Progression in 3 mo | Presence of disease progression within 3 mo from sample aquisition | 3 month |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival (OS) | Time from sample aquisition to death from any reason | Up to 5 years |
| Progression free survival | Time from sample aquisition to progression or death from the disease |
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Inclusion Criteria:
Exclusion Criteria:
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The study will include patients with solid tumours receiving systemic therapy for their disease who do not have other significant factors that affect the immune system
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aleksei Novik, MD, PhD | Contact | +78124399505 | alexey.viktorovich.novik@gmail.com | |
| Tatiana Nekhaeva, MD, PhD | Contact | +78124399514 | nehaevat151274@mail.ru |
| Name | Affiliation | Role |
|---|---|---|
| Irina Baldueva, MD, PhD, DSc | N.N. Petrov NMRC of Oncology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| N.N. Petrov NMRC of Oncology, Oncoimmunology dep. | Recruiting | Saint Petersburg | 197758 | Russia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | Shendaleva N, Novik AV, Zozulya A, Nekhaeva TL, Semenova A, Teletaeva GM, et al. Impact of the azoximer bromide concomitant therapy on patient outcomes in patients with melanoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021;39(15_suppl):e21574-e. | ||
| Result | Novik AV, Shendaleva N, Zozulya A, Nekhaeva TL, Semenova A, Teletaeva GM, et al. Impact of the azoximer bromide concomitant therapy on outcomes in patients with soft tissue sarcoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021;39(15_suppl):e23534-e. | ||
| Result | Novik AV, Girdyuk DV, Nekhaeva TL, Emelyanova NV, Semenova A, Teletaeva GM, et al. Progression prediction model for solid tumors with clinical and immunological parameters. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021;39(15_suppl):2539. |
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Upon completion, the database is planned to be published with depersonalized data for cohorts with meaningful data. Cohorts to be published will be defined upon data check. Partial publications could be applicable.
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Blood, peripheral blood mononuclear cells, plasma, serum, living tumor tissue, archive tumor tissue
| Up to 5 years |
| Response rate | Response assesmenr with RECIST 1.1 and iRECIST | During the intervention |
| ID | Term |
|---|---|
| D001932 | Brain Neoplasms |
| D008545 | Melanoma |
| D012509 | Sarcoma |
| D015179 | Colorectal Neoplasms |
| D007680 | Kidney Neoplasms |
| D011471 | Prostatic Neoplasms |
| ID | Term |
|---|---|
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009380 | Neoplasms, Nerve Tissue |
| D018326 | Nevi and Melanomas |
| D012878 | Skin Neoplasms |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D018204 | Neoplasms, Connective and Soft Tissue |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D014571 | Urologic Neoplasms |
| D014565 | Urogenital Neoplasms |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052801 | Male Urogenital Diseases |
| D005834 | Genital Neoplasms, Male |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D011469 | Prostatic Diseases |
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