This study was conducted for assessment of adherence of Rheumatoid Arthritis patients to Methotrexate as a gold standard drug for treatment of R.A. Moreover, evaluating the effect of drug adherence to patient quality of life.

Rheumatoid arthritis one of most common autoimmune diseases. characterized by numerous complications which may affect patient quality of life. Hence, this review aim to search the relation between patient"s drug adherence and clinical health outcome. our review utilizing survey as a tool to collect needed data from rheumatoid patients. survey consisted of number of questions , participants were required to answer these questions. participation to this questionnaire was optional.

Inclusion Criteria:

1. The study was carried out among all RA patients (adults patients ≥ 18 years).
2. Patients not suffering from severe mental disorders.
3. Patients with a disease duration from (1-5) years.
4. Patients on MTX treatment from (1-5) years.
5. Patients taking MTX alone or in combination with other DMARDs.

Exclusion Criteria:

1. Patient who on MTX for more than 5 years

2. Patient who have complications like:-

   • History of liver or kidney disease
   • Diabetic patients
   • Hypertensive patients
   • Bone marrow hypoplasia
   • Leukopenia or significant anemia
   • Peptic ulcer or any GIT problems
   • Hereditary alopecia.

The survey participants were adults diagnosed as RA patients in accordance to 2010 ACR/EULAR classification criteria.