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| Name | Class |
|---|---|
| SRW | UNKNOWN |
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SRW Laboratories has formulated the Cel System protocol, a group of three formulas designed to interact with each of the 9 Hallmarks of Aging and combined this with an App that supports positive lifestyle changes, with a view that, if we can positively impact each Hallmark, we can support healthy aging.
This study will measure the impact of the Cel System protocol on the biological clocks of the participants, as well as measure established biomarkers associated with the 9 Hallmarks and note any aesthetic changes you may experience to establish evidence of the effect of the Cel System Protocol over time.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SRW Cel system | Experimental | Cel1, Cel2, Cel3 Patients will take all three supplements once daily. Patients will take 2 capsules of each supplement in the morning with food. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SRW Cel System | Dietary Supplement | Dietary supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Biological age | The primary outcome measure for the study is biological age, measured by DNA methylation, using blood and saliva samples collected from patients. | Change in epigenetic age from baseline to 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory marker IL-6 | (IL-6 will also be assessed at 3, 6, and 12 months. | Change in inflammatory marker from baseline to 12 months |
| C-reactive protein | C-reactive protein will also be assessed at 3, 6, and 12 months. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Regenerative Wellness Center | Recruiting | Salt Lake City | Utah | 84117 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35358003 | Background | Blagosklonny MV. Cell senescence, rapamycin and hyperfunction theory of aging. Cell Cycle. 2022 Jul;21(14):1456-1467. doi: 10.1080/15384101.2022.2054636. Epub 2022 Mar 31. | |
| 33919088 | Background | Bungau S, Vesa CM, Abid A, Behl T, Tit DM, Purza AL, Pasca B, Todan LM, Endres L. Withaferin A-A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases. Molecules. 2021 Apr 21;26(9):2407. doi: 10.3390/molecules26092407. |
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| Change in inflammatory marker from baseline to 12 months |
| 35098970 | Background | Gonzales MM, Garbarino VR, Marques Zilli E, Petersen RC, Kirkland JL, Tchkonia T, Musi N, Seshadri S, Craft S, Orr ME. Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial. J Prev Alzheimers Dis. 2022;9(1):22-29. doi: 10.14283/jpad.2021.62. |
| 32411700 | Background | Hong W, Mo F, Zhang Z, Huang M, Wei X. Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism. Front Cell Dev Biol. 2020 Apr 28;8:246. doi: 10.3389/fcell.2020.00246. eCollection 2020. |
| 31214247 | Background | Hassan FU, Rehman MS, Khan MS, Ali MA, Javed A, Nawaz A, Yang C. Curcumin as an Alternative Epigenetic Modulator: Mechanism of Action and Potential Effects. Front Genet. 2019 Jun 4;10:514. doi: 10.3389/fgene.2019.00514. eCollection 2019. |