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Standard care for locally advanced rectal cancer consists in a neoadjuvant therapy followed by surgery. Morbidity and mortality remain high after rectal surgery, and often linked with quality of life impairment. 10 to 30% present a pathological complete response after neoadjuvant therapy. Some surgical teams propose "watch and wait" approach for patients selected with clinical complete responses criterion. The problem is to be sur the response is complete. MRI seems to be accurate to select complete responders. We will try to find MRI criterion of complete responses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pathological complete response | Patients with a complete response to the neoadjuvant therapy on the definitive anatomopathology study. | ||
| Non pathological complete response | Patients without complete response to the neoadjuvant therapy on the definitive anatomopathology study. |
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| Measure | Description | Time Frame |
|---|---|---|
| Complete response MRI criterion | We selected several objective MRI criterion among literature and compared them between the two groups. | Day 0: immediately after the procedure |
| Measure | Description | Time Frame |
|---|---|---|
| MRI accuracy | Calculated Sensitivity, Specificity, Positive Predictive Value and Negative Predictive Value. | Day 0: immediately after the procedure |
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Inclusion Criteria:
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Digestive surgery department
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu de Nîmes | Nîmes | GARD | 30000 | France |
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| ID | Term |
|---|---|
| D012004 | Rectal Neoplasms |
| D000095384 | Pathologic Complete Response |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
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| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D018450 | Disease Progression |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |