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| Name | Class |
|---|---|
| Beijing Tongren Hospital | OTHER |
| Beijing Obstetrics and Gynecology Hospital | OTHER |
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Tinnitus, hearing loss and vertigo are the three major diseases of otology, affecting hundreds of millions of people in our country, and are major health problems. Ear structures and lesions are deeply embedded in the bone, and CT is the preferred examination technique. The key structures of the ear are small and the lesions are hidden. Spiral CT is "not visible" and "undiagnosed" due to insufficient spatial resolution. The ultra-high-resolution CT independently developed by our team has a spatial resolution of 50 μm, which is 6 times higher than that of high-end spiral CT, and solves the problem of "not showing" ear diseases. However, with the transformation of imaging modes and the improvement of display capabilities, the imaging system of helical CT is no longer applicable. It is urgent to carry out systematic research to create matching imaging plans, imaging anatomy standards and disease assessment standards to solve the problem of "undiagnosed". problem. This project plans to build an adult and pediatric imaging solution based on ultra-high-resolution CT to optimize image quality and radiation dose; comprehensively evaluate conduction, sensory, and surgical-related fine structures of the ear, and establish a new 0.1mm-scale image anatomy atlas; A prospective study conducted by the center analyzes the hidden pathological changes of tinnitus, deafness and vertigo, evaluates the diagnostic efficacy of ultra-high-resolution CT for the above diseases, and establishes new diagnostic criteria for lesion detection, symptom correlation, and efficacy evaluation. This project will bring new changes to the practice of otology clinical diagnosis and treatment
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Age under 18 | Participants under the age of 18 |
| |
| Age 18-30 | Participants aged 18-30 |
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| Age 31-40 | Participants aged 31-40 |
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| Age 41-50 | Participants aged 41-50 |
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| Age 51-60 | Participants aged 51-60 |
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| Age ≥61 | Participants aged ≥61 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ultra-high-resolution computed tomography exams | Diagnostic Test | Participants in the age groups undergo ultra-high-resolution computed tomography exam |
|
| Measure | Description | Time Frame |
|---|---|---|
| Subjective and objective evaluation methods for CT image quality | Image quality (Likert score) and image noise will be combined to report the optimal image quality-noise combination | 2022.1-2024.12 |
| Radiological anatomy of normal ears based on ultra-high resolution CT | diameters in milimeter | 2022.1-2024.12 |
| Radiological anatomy of normal ears based on ultra-high resolution CT | angle in degree | 2022.1-2024.12 |
| Quantitative diagnostic standard for ear diseases based on U-HRCT image | shape and position of conductive and senserineural hearing pathways | 2022.1-2024.12 |
| Quantitative diagnostic standard for ear diseases based on U-HRCT image | size in milimeter of conductive and senserineural hearing pathways | 2022.1-2024.12 |
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For healthy volunteers
Inclusion Criteria:
Exclusion Criteria:
For patients with otological diseases
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pengfei Zhao, Prof. | Contact | +8613811048563 | zhaopengf05@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Zhenchang Wang, Prof. | Beijing Friendship Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Friendship Hospital, Capital Medical University | Recruiting | Beijing | Beijing Municipality | 100050 | China |
The project team has not decided the ways to share the data.
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| ID | Term |
|---|---|
| D034381 | Hearing Loss |
| D014012 | Tinnitus |
| D014717 | Vertigo |
| D004194 | Disease |
| ID | Term |
|---|---|
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
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| D009461 |
| Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D015837 | Vestibular Diseases |
| D007759 | Labyrinth Diseases |
| D010335 | Pathologic Processes |