Compression Therapy as a Prophylactic Method Against CIPN: a Prospective Self-controlled Trial

Compression Therapy as a Prophylactic Method Against Paclitaxel-induced Peripheral Neuropathy: a Prospective Self-controlled Trial

This is a single-center, self-controlled, evaluator-blinded prospective study, which applies pressurized gloves and foot caps to prevent paclitaxel-induced peripheral neuropathy in patients with nasopharyngeal carcinoma.

Inclusion Criteria:

• Age range from 18 to 70
• ECOG physical status score: 0-2
• Newly diagnosed patients who have not received antitumor therapy
• Nasopharyngeal carcinoma confirmed by pathology
• Paclitaxel is included in the chemotherapy regimen
• Laboratory examination results within one week before enrollment should meet the following conditions: neutrophils (ANC) ≥1.5×109/L, platelets (PLT) ≥80×109/L, total bilirubin (TBI) ≤1.5× upper limit of normal value (2mg/ dL), ALT and AST ≤2× upper limit of normal value
• Patients voluntarily participate and provide written informed consent

Exclusion Criteria:

• Patients with peripheral neuropathy, hand-foot syndrome, and dermatomyositis
• Patients with missing fingers or toes
• Patients with Raynaud's syndrome and peripheral vascular ischemia
• Pregnant or lactating women
• Those considered unsuitable for inclusion by the researcher