To investigate the clinical application of ultrasound-guided continuous low serratus anterior plane block in open surgery for hepatocellular carcinoma.

METHODS: Patients with hepatocellular carcinoma who attended our hospital from January 2021 to April 2023 were divided into CS group and N group according to the random number table method; CS group underwent ultrasound-guided continuous low anterior serratus plane block and N group underwent ultrasound-guided single anterior serratus plane block combined with rectus abdominis sheath block; the operation time, anesthesia time, incision length, sensory block time and sensory block maintenance time were counted and recorded. Pain score (NRS) was used to detect analgesia; alanine aminotransferase (ALT), liver function aspartate aminotransferase (AST), and prothrombin time (The time of thrombin, NRS) were measured by fluorescent quantitative PCR. （The time of thrombin (APTT), total bilirubin (TBIL) levels and adverse reactions.

Inclusion Criteria:

1. Age 18-60 years;
2. ASAI-II;
3. BMI: 18-29 kg/m2

Exclusion Criteria:

1. Combined cardiac, cerebral, hepatic, and renal failure;
2. Comorbid psychiatric and neuromuscular disorders;
3. A history of allergy to anesthetic drugs;
4. Participation in other recent clinical or drug trials.

We plan to share this research plan with other researchers

It is expected to be shared in 2023

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