HLH Patients - a Retrospective Study

Retrospective Analysis of the Outcome of Patients Diagnosed With Hemophagocytic Lymphohistiocytosis (HLH) Treated at the S.C.Pediatric Oncohematology of the Regina Margherita Torino Hospital (OIRM)

Monocentric, observational, retrospective, no profit study aimed to analyze factors that are significantly impacting the outcome of patients diagnosed with HLH.

retrospective data collection to study: type of HLH familial vs secondary, sex, age, presence of infectious cause, involvement central nervous system ( SNC), hepatic involvement, presence of hemophagocytosis, presence of splenomegaly, presence of involvement of other organs, the value of neutrophils (PMN), the value of hemoglobin, platelets, albumin, triglycerides, ferritin, LDH, type of therapy and the response to therapy after 2 months

Inclusion Criteria:

• Have received HLH diagnosis according to HLH 2004 criteria
• age ⥶18 years.
• followed at our facility between January 2004 and December 2021
• Whose parents have consented to participation and data processing

Exclusion Criteria:

• The study does not foresee specific exclusion criteria other than the non-compliance with the inclusion criteria