Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The web-based continuity of care intervention model to provide comprehensive nursing interventions for obese children with NAFLD, always tracking their performance status, enabling them to grasp the knowledge of healthy weight loss, develop good lifestyle habits, and reduce their weight, thus reducing the incidence of NAFLD in children.
The web-based continuity of care intervention model to provide comprehensive nursing interventions for obese children with NAFLD, always tracking their performance status, enabling them to grasp the knowledge of healthy weight loss, develop good lifestyle habits, and reduce their weight, thus reducing the incidence of NAFLD in children.The primary outcome are serum biomarkers such as alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) . Second outcomes are: aspartate aminotransferase, and liver imaging (liver ultrasound and magnetic resonance imaging), BMI, waist-to-hip ratio and quality of life. In addition, socio-demographic characteristics such as age, gender and ethnicity will be recorded. All outcomes were measured at baseline, week 4, week 16, week 24, week 36, and week 48 to determine the trajectory of change in outcome variables over intervention process.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| web-based intervention | Experimental |
|
|
| the control group | No Intervention | 1. Routine care.At each visit to the hospital, in this time, the child and his parents are given health education on diet and exercise booklets, and the parents supervise the child's daily life. The team members will review the child's condition every month for feedback. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| web-based intervention | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| The change of alanine aminotransferase（ALT）and gamma-glutamyl transferase（GGT） | The primary outcome are serum biomarkers such as alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) . | Change from Baseline ALT and GGT at 48 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The change of aspartate aminotransferase | Second outcome is aspartate aminotransferase | Change from Baseline aspartate aminotransferase at 48 weeks |
| The change of liver imaging | Third outcome is liver imaging |
| Measure | Description | Time Frame |
|---|---|---|
| socio-demographic characteristics such as age, gender and ethnicity | In addition, socio-demographic characteristics such as age, gender and ethnicity will be recorded. | baseline |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Caixia Tian, MSc | Shaoxing Maternity and Child Health Care Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Caixia Tian | Shaoxing | Zhejiang | 312000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36339187 | Derived | Tian C, Xu J, Wang G, Yu L, Tang X. The effectiveness of web-based interventions on non-alcoholic fatty liver disease (NAFLD) in obese children: A study protocol for a randomized controlled trial. Front Public Health. 2022 Oct 20;10:930901. doi: 10.3389/fpubh.2022.930901. eCollection 2022. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| D063766 | Pediatric Obesity |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D009765 | Obesity |
Not provided
Not provided
web-based intervention
Not provided
Not provided
Study personnel involved in the data assessment of the study are blinded to the patients' treatment assignment. The clinical doctors that deliver the study treatment are not blinded and are therefore uninvolved in the patients' data assessments related to this study. Data analysts are blinded to group allocation.
|
| Change from Baseline liver imaging at 48 weeks |
| The change of BMI | Fourth outcome is BMI | Change from Baseline BMI at 48 weeks |
| The change of waist-to-hip ratio | Fifth outcome is waist-to-hip ratio | Change from Baseline waist-to-hip ratio at 48 weeks |
| The change of quality of life | Sixth outcome is quality of life | Change from Baseline quality of life at 48 weeks |
| D050177 |
| Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |