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The respiratory complications of esophageal atresia have already been identified.
They are mainly related to tracheomalacia linked to the esophageal malformation, and are aggravated by frequently associated gastroesophageal reflux.
In this context, symptoms of asthma (or bronchial hyperreactivity) occur more frequently than in the general population and persist into adulthood. Their pathogenesis is still poorly understood and is the subject of much discussion.
The therapeutic management of these respiratory complications, poorly codified, remains very heterogeneous from one center to another. In France, the summary of knowledge is updated by the Reference Center for chronic and malformative diseases of the esophagus.
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| Measure | Description | Time Frame |
|---|---|---|
| Retrospective study of respiratory complications of esophageal atresia in children | Files analysed retrospectively from January 01, 2010 to December 31, 2020 will be examined |
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Inclusion criteria:
Exclusion criteria:
Subject and/or parental authority having expressed their opposition to participating in the study
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Child aged 1 to 12 years old operated on for esophageal atresia and followed up at the University Hospitals of Strasbourg
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| Name | Affiliation | Role |
|---|---|---|
| Laurence WEISS, MD | Centre de Ressources et de Compétences de la Mucoviscidose (CRCM) - CHU de Strasbourg - France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de Ressources et de Compétences de la Mucoviscidose (CRCM) - CHU de Strasbourg - France | Strasbourg | 67091 | France |
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| ID | Term |
|---|---|
| D004933 | Esophageal Atresia |
| D005764 | Gastroesophageal Reflux |
| D001249 | Asthma |
| D016535 | Bronchial Hyperreactivity |
| ID | Term |
|---|---|
| D004065 | Digestive System Abnormalities |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
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| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D015154 | Esophageal Motility Disorders |
| D003680 | Deglutition Disorders |
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |