Ursodeoxycholic Acid in C. Difficile Infection

Feasibility Studies to Investigate the Role of Ursodeoxycholic Acid in the Prevention of Recurrence of C. Difficile Infection

The primary objective of the study is to assess tolerability and adherence to treatment with ursodeoxycholic acid

Inclusion Criteria:

• Completion of a course of antibiotic treatment for C. difficile infection within the previous 7 days

Exclusion Criteria:

• • Pregnant or Breast-feeding

  • Gall bladder inflammation
  • Frequent episodes of biliary colic
  • Occlusion of the common bile duct or cystic duct
  • Active small intestinal inflammation
  • Previous resection of distal small intestine
  • Treatment with bile salt binding agents, ciclosporin or ciprofloxacin
  • Diarrhoea (from any cause) at study initiation
  • hypersensitivity to bile acids or any excipient of the formulation
  • Life expectancy less than 6 months