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This study aimed to evaluate the relation between the levels of (Brain Derived Neurotropic Factor) BDNF and val66met polymorphism of BDNF gene, and the presence of depression in type 2 diabetes. In addition to studying the relationship between BDNF level and val66met polymorphism of its gene and assessing relation between BDNF level and obesity.
The study included 88 type 2 diabetic patients, which are further divided into two groups; depressed and non-depressed. Depression was assessed by Hamilton Depression Rating Scale (HAM-D) and structured clinical interview for DSM-IV Axis disorder (SCID-I) for diagnosing depression and exclusion of other psychiatric disorders. Genotyping was performed by using Real Time-PCR (TaqMan probes).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with type 2 Diabetes Mellitus and depression | Active Comparator | This arm includes patients with type 2 diabetes mellitus that were diagnosed with depression using structured clinical interview for DSM-IV Axis disorder (SCID-I) and Hamilton Depression Rating Scale (HAM-D) for diagnosing depression and exclusion of other psychiatric disorders. |
|
| Patients with type 2 Diabetes Mellitus and no depression | Active Comparator | This arm includes patients with type 2 diabetes mellitus where depression was ruled out using structured clinical interview for DSM-IV Axis disorder (SCID-I) and Hamilton Depression Rating Scale (HAM-D) for diagnosing depression and exclusion of other psychiatric disorders. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Questionare | Other | Assessing the presence or the absence of depression: By structured clinical interview for DSM-IV Axis disorder (SCID-I) and Hamilton Depression Rating Scale (HAM-D) for diagnosing depression and exclusion of other psychiatric disorders. |
| Measure | Description | Time Frame |
|---|---|---|
| BDNF level in blood | Measurement of the level of BDNF in blood | 1 day (At the time of recruitment) |
| val66met polymorphism of BDNF gene | Measurement of val66met polymorphism of BDNF gene | 1 day (At the time of recruitment) |
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Adult patients who have type two diabetes with or without depression.
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| Name | Affiliation | Role |
|---|---|---|
| Tarek Abdelaziz, PhD | Kasr Alaini University Hsopitals | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo university hospitals | Cairo | Egypt |
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| ID | Term |
|---|---|
| D003863 | Depression |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| D009750 |
| Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |