Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
In Switzerland, approximately 20'000 persons suffer a stroke each year. Despite carefully considered rehabilitation programs, full recovery is achieved only in a small proportion of stroke survivors (www.swissheart.ch). Studies suggest that motor-cognitive trainings can improve gait, balance, and mobility in chronic stoke survivors. However, little is known about the effect of motor-cognitive trainings on cognitive functioning in chronic stroke.
The aim of this study is to evaluate the effects of a motor-cognitive training added to usual care compared to usual care alone on cognitive functions, single- and dual-task mobility, gait and health-related quality of life.
In this single-blind RCT, 38 participants will be allocated randomly to either the intervention group (usual care + motor-cognitive training by means of an exergame for 12 weeks, 2x/week for 30-40 minutes) or the control group (usual care only). Both groups will attend three assessments, at baseline, post-intervention (12 weeks after baseline), and at follow-up (24 weeks after baseline). Global cognitive functioning will be the primary endpoint and a linear mixed model will be used for analysis.
Motor-cognitive trainings, especially exergames, bear the potential for further development of innovative long-term rehabilitation solutions for chronic stroke survivors. Cognitive deficits are a common unmet need restricting daily activities mentioned by chronic stroke survivors. Exergame training following personally tailored progression to generate optimal training load may help addressing this unmet need. Therefore, this study will contribute to the on-going research objective on how to improve the long-term care of stroke patients.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention Group | Experimental | Usual care + concept-guided, personalized, motor-cognitive training by means of an exergame |
|
| Control Group | No Intervention | Usual care only |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Concept-guided, personalized, motor-cognitive training by means of an exergame | Other | 12 weeks, two times per week for 30-40min |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of Montreal Cognitive Assessment Score | Widely used screening tool and cognitive outcome in neurological patients including stroke | week 0, week 12 and week 24 |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Stroke Impact Scale 3.0 Score | Stroke-specific measurement tool assessing patient-reported health-related quality of life | week 0, week 12 and week 24 |
| Change of Simple Reaction Test Parameters |
| Measure | Description | Time Frame |
|---|---|---|
| Compliance Rate | attended sessions / offered sessions | week 12 |
| Adherence Rate | attended training time / offered training time | week 12 |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kantonsspital Winterthur | Winterthur | Canton of Zurich | 8400 | Switzerland | ||
| Ambulante Reha Triemli Zürich |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40182756 | Derived | Huber SK, Knols RH, Held JPO, Betschart M, Gartmann S, Nauer N, de Bruin ED. PEMOCS: effects of a concept-guided, PErsonalized, MOtor-Cognitive exergame training on cognitive functions and gait in chronic Stroke-a randomized, controlled trial. Front Aging Neurosci. 2025 Mar 13;17:1514594. doi: 10.3389/fnagi.2025.1514594. eCollection 2025. | |
| 38965612 |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
Not provided
Not provided
RCT
Not provided
Not provided
Not provided
Widely used reliable and valid neuropsychological test assessing alertness
| week 0, week 12 and week 24 |
| Change of Trail Making Test A & B Parameters | Widely used reliable and valid neuropsychological test assessing processing speed and executive functions | week 0, week 12 and week 24 |
| Change of Stroop Interference Test Parameters | Widely used reliable and valid neuropsychological test assessing the ability to inhibit the reaction to a more dominant stimulus in favour of the inquired reaction to a less dominant stimulus | week 0, week 12 and week 24 |
| Change of N-back test Parameters | Widely used reliable and valid neuropsychological test assessing working memory and related cognitive functions | week 0, week 12 and week 24 |
| Change of Mental Rotation Test Parameters | Measures the ability to mentally rotate abstract objects | week 0, week 12 and week 24 |
| Change in Single- and cognitive Dual-Task Timed Up and Go Test Parameters and motor/cognitive dual task costs | Widely used, reliable and valid test of mobility and dual-task ability in various populations including stroke. | week 0, week 12 and week 24 |
| Change of 10 meter walk test Gait Parameters | Widely used test to assess gait speed and spatiotemporal gait parameters. | week 0, week 12 and week 24 |
| Change of Outdoor Gait Parameters | Assesses walking endurance and spatiotemporal gait parameters under daily-life conditions. | week 0, week 12 and week 24 |
| Perceived Motor-Cognitive Task Difficulty | visual analogue scale after each training session, based on cognitive load theory, scale from 1-9, where 9 symbolizes most difficult | twice per week, week 0-12 |
| Perceived Performance | visual analogue scale after each training session, performance item of the National Aeronautics and Space Administration - Task Load Index, scale from 0 to 20, where 20 symbolizes highest performance | twice per week, week 0-12 |
| Dose and Content of Usual Care | according to weekly questionnaire, based on TIDIeR checklist | once per week, week 0-24 |
| Amount and Intensity of General Physical and Cognitive Activity | according to weekly questionnaire, based on TIDIeR checklist | once per week, week 0-24 |
| Zurich |
| 8063 |
| Switzerland |
| University Hospital Zürich | Zurich | 8091 | Switzerland |
| Huber SK, Knols RH, Held JPO, Betschart M, de Bruin ED. PEMOCS: Evaluating the effects of a concept-guided, PErsonalised, MOtor-Cognitive exergame training on cognitive functions and gait in chronic Stroke-study protocol for a randomised controlled trial. Trials. 2024 Jul 4;25(1):451. doi: 10.1186/s13063-024-08283-7. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |