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| Name | Class |
|---|---|
| Toronto Rehabilitation Institute | OTHER |
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Women with breast cancer who are referred to the cardiac rehabilitation program at the Toronto Rehabilitation Institute will be invited to enrol in this observational study. Participants will take part in an established 16-week multimodal cardiac rehabilitation program (HEALTh program) at Toronto Rehabilitation Institute and outcome measures will be assessed before and after program participation to determine the effectiveness of the program in improving cardio metabolic health. Change in VO₂peak will be assessed using Cardiopulmonary Exercise Test (CPET). Traditional cardiac risk factors, lifestyle behaviours, exercise adherence, health-related quality of life, and fatigue will also be assessed.
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| Measure | Description | Time Frame |
|---|---|---|
| Cardiopulmonary Fitness | VO2peak assessed using cardiopulmonary exercise test | post-intervention (16 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Visceral adipose tissue | Measured only in a subset (n=30) of participants via 1.5T MRI. | post-intervention (16 weeks) |
| Left ventricular ejection fraction | Measured only in a subset (n=30) of participants via 1.5T MRI. |
| Measure | Description | Time Frame |
|---|---|---|
| Smoking Status | Smoking assessment history questionnaire | post-intervention (16 weeks) |
| Moderate-Intensity Physical Activity Time | PiezoRx® will be worn by participants for 7 days with data used to assess moderate activity time (>100 steps per minute) |
Inclusion Criteria:
Exclusion Criteria:
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Female early-stage breast cancer survivors.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Amy A Kirkham, PhD | Contact | (416) 946-4069 | amy.kirkham@utoronto.ca |
| Name | Affiliation | Role |
|---|---|---|
| Amy Kirkham, PhD | University of Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Toronto Rehabilitation Institute | Recruiting | Toronto | Ontario | Canada |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| post-intervention (16 weeks) |
| Native myocardial T1 time | Measured only in a subset (n=30) of participants via 1.5T MRI. | post-intervention (16 weeks) |
| Left ventricular mass | Measured only in a subset (n=30) of participants via 1.5T MRI. | post-intervention (16 weeks) |
| lipid profile | Assessed via fasting blood draw | post-intervention (16 weeks) |
| Fasting glucose | Assessed via fasting blood draw | post-intervention (16 weeks) |
| hemoglobin A1c | Assessed via fasting blood draw | post-intervention (16 weeks) |
| Cancer-specific, health-related quality of life | Functional Assessment of Cancer Therapy (FACT) questionnaire. Minimum score = 0, maximum score = 108, with higher score representing better quality of life. | post-intervention (16 weeks) |
| Depressive symptoms | Patient Health Questionnaire 9 scale. Minimum value = 0, maximum value = 27, where higher score represents more depressive symptoms. | post-intervention (16 weeks) |
| Psychosocial Stress | Perceived Stress Scale (PSS). Minimum value = 0, maximum value = 56, where higher score represents more perceived stress. | post-intervention (16 weeks) |
| Cancer-related fatigue | Fatigue sub-scale of the Functional Assessment of Cancer Therapy (FACT) questionnaire. Minimum score = 0, maximum score = 52, with higher score representing less fatigue. | post-intervention (16 weeks) |
| averaged over 7 days post-intervention |
| Vigorous-intensity Physical Activity | PiezoRx® will be worn by participants for 7 days with data used to assess vigorous activity time (>120 steps per minute) | averaged over 7 days post-intervention |
| Physical Activity Bouts per Day | PiezoRx® will be worn by participants for 7 days with data used to assess bouts of physical activity per day (greater than 10 minutes of moderate/vigorous activity) | averaged over 7 days post-intervention |
| Total daily steps | PiezoRx® will be worn by participants for 7 days with data used to assess total daily steps | averaged over 7 days post-intervention |
| Self-Reported Physical Activity | Godin Leisure Time Physical Activity Questionnaire | post-intervention (16 weeks) |
| Diet quality | Rapid Eating and Activity Assessment for Participants (REAP) questionnaire. Minimum score = 13, maximum score = 39, with a higher score indicating a higher diet quality. | post-intervention (16 weeks) |
| D017437 |
| Skin and Connective Tissue Diseases |