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Thyroid gland diseases are the second most common endocrine disease following diabetes mellitus(1). Thyroid nodules are common disorders with a prevalence ranged from 4 to 7% in adult population, 5%-30% are malignant [1].Fine-needle aspiration cytology (FNAC) is an easy, cost-effective test for cancer diagnosis, and its use has markedly decreased the number of unnecessary thyroid surgeries(2).
it should be noted that FNAC cannot differentiate between benign and malignant follicular neoplasms.differentiation between follicular adenoma and follicular carcinoma is only possible after thyroid lobectomy.[2,3] In addition, a study of FNAC showed that 68% of the cases diagnosed by FNAC as follicular neoplasm turned out to be the follicular type of papillary carcinoma, indicting a considerable overlap between benign and malignant neoplasms.[4] Incidental findings of thyroid nodules have increased exponen¬tially in recent years, mostly due to the widespread application of high-resolution ultrasound (US) to the thyroid [5].Several in¬ternational scientific societies have established clinic-radiolog¬ical guidelines for the diagnosis and the management of thy¬roid nodules [2,3]. The American College of Radiology identifies 5 radiological risk levels and recommends US-guided fine-nee¬dle aspiration cytology (US-FNAC) of high-suspicion nodules if 10 mm or larger, and of nodules with a low risk for malignan¬cy only if larger than 25 mm [2]. According to the European Thyroid Association Guidelines (EU-TIRADS), nodules with no high-risk features (oval-shaped, isoechoic/hyperechoic with smooth margins) should be considered at low risk and FNA performed only if greater than 20 mm, while high-risk nodules greater than 10 mm should undergo FNAC, with possible FNAC also in 5-10 mm nodules if highly suspicious [3].
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| FNAC | Experimental |
| |
| post operative hitopathology | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fine Needle Aspiration Cytology | Procedure | Comparison between FNAC and post operative specimen after thyroid surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of true positive results of FNAC after thyroidectomy | Accuracy of FNAC in thyroid nodules compared to to surgical specimen : QOC experience | 10 days |
| Percentage of malignant thyroid nodules not observed by FNAC | type of thyroid malignancy not observed by FNAC | 10 days |
| Incidence of false negative results by FNAC | false negative that diagnosed by FNAC not malignant but proved malignancy after surgical excion | 10 days |
| Percentage of Total number of true results of FNAC to the total number of cases | accuracy of FNAC | 10 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Amr M Makky, specialist surgical onclogy | Qena Oncology Center- Medical Military Academy | Study Director |
| Abdullah Atyah Ali, Ass.Lecture General Surgery | Qena Oncology Center--Luxor University | Study Director |
| Mohamed Ahmed Orabi, specialist surgical onclogy | Qena Oncology Center | Principal Investigator |
| Mina Romany Tawfeek | Qena Oncology Center | Study Chair |
| Mahmoud Ahmed Dosoky, specialist pathology | Qena Oncology Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Qena Oncology Center | Qina | +2 | Egypt |
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| ID | Term |
|---|---|
| D013959 | Thyroid Diseases |
| D016606 | Thyroid Nodule |
| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
| D013964 | Thyroid Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
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|
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |