Cushing's Syndrome Before and After Treatment (CORRECT)

Effects of CORtisol Excess and REmission in Cushing's Syndrome Over Time (CORRECT): A Prospective Non-interventional Cohort Study

The purpose of this study is to prospectively study patients with Cushing's syndrome before and after treatment, with a special emphasis on physical function, quality of life, and circadian rhythms.

The hypotheses are:

• Cushing's syndrome negatively impacts health-related quality of life (HRQoL) and physical functioning
• Cushing's syndrome is associated with altered circadian rhythms at the whole body level and in peripheral target tissues.
• These complications partially reverse following disease control.

Inclusion Criteria:

• New (≤ 2 months) diagnosis of Cushing's syndrome (CS) of endogenous etiology:

  • ACTH-dependent CS
  • ACTH-independent CS

• Age >18 years

• Written informed consent

Exclusion Criteria:

• Active cancer
• Iatrogenic or malignant cause of CS such as adrenocortical carcinoma
• Chronic heart failure (New York Heart Association class IV)
• Chronic kidney disease Chronic Kidney Disease stage ≥3 (eGFR >30 ml/min)
• Liver disease in the form of cirrhosis
• Deemed unable to complete the study safely by investigator