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The purpose of this study is to examine if the changes in corticospinal function that accompany ACL reconstruction can be improved through a form of mental coaching and encouragement, known as operant conditioning.
It is theorized reduced corticospinal excitability contributes to quadriceps dysfunction after knee injury and joint disease. Current rehabilitation does not directly target the alterations in corticospinal excitability, which may limit recovery. Operant conditioning is an emerging approach capable of increasing corticospinal excitability by directly targeting the corticospinal pathways. However, it remains to be determined whether operant conditioning of the corticospinal pathway may improve corticospinal function after knee trauma. Therefore, this study will evaluate the ability of operant up-conditioning of the corticospinal pathway to improve corticospinal function after ACL reconstruction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Operant Conditioning | Experimental | Motor evoked responses will be elicited along with operant conditioning training for about 2 weeks |
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| Control | Experimental | Motor evoked responses will be elicited without operant conditioning training for about 2 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Operant Conditioning | Behavioral | Active encouragement and feedback to increase motor evoked response during stimulation. |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in corticospinal excitability | Corticospinal excitability will be measured using transcranial magnetic stimulation at baseline and post-intervention and will be compared between groups. | Baseline (before the start of the intervention) and post-intervention (approximately 2 weeks after baseline) |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in quadriceps strength | Isometric quadriceps strength will be measured using an isokinetic dynamometer. Quadriceps strength will be measured prior to the intervention and immediately following the intervention. | Baseline (before the start of the intervention) and post-intervention (approximately 2 weeks after baseline) |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Michigan | Ann Arbor | Michigan | 48109 | United States |
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| ID | Term |
|---|---|
| D000070598 | Anterior Cruciate Ligament Injuries |
| ID | Term |
|---|---|
| D007718 | Knee Injuries |
| D007869 | Leg Injuries |
| D014947 | Wounds and Injuries |
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| Control | Behavioral | Absence of active encouragement and feedback to increase motor evoked response when stimulated. |
|
| Changes in quadriceps voluntary activation |
Voluntary activation will be measured using an electrical superimposition technique. Voluntary activation will be measured prior to the intervention and immediately following the intervention. |
| Baseline (before the start of the intervention) and post-intervention (approximately 2 weeks after baseline) |