Relation Between Protein 13 and Gestational Hypertensive Disorder

Low Serum Pregnancy Protein 13 Early in Pregnancy Might Predict the Oncoming Gestational Hypertensive Disorders, Especially Early-onset Preeclampsia

the attendants of the clinic with a one-missed period (T0) underwent determination of baseline blood pressure (BP) measures and gave blood samples for estimation of levels of placental growth factor (PLGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and pregnancy protein 13 (PP13). The same evaluation was repeated on the 6th, 24th, 32nd, and 36th gestational week (GW). Twenty non-pregnant women gave samples as a negative control group.

Inclusion Criteria:

• Normotensive women who attended the clinic with a one-missed period (T0)

Exclusion Criteria:

• History of essential hypertension (HTN)
• renal diseases
• hepatic diseases
• cardiac diseases
• metabolic syndrome
• body mass index (BMI) >35 kg/ m2
• congenital heart diseases