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The investigators are suggtesting that lower goals of systolic blood pressure after intravenous thrombolysis may reduce the risk of hemorrhagic complications and improve functional outcomes after acute ischemic stroke.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group. Standart care | No Intervention | Standart hemodynamic goals: systolic blood pressure 160-185 mmHg in first 24 hours after intravenous thrombolysis | |
| Systolic blood pressure ≤ 160 mmHg | Experimental | Lower hemodynamic goals: systolic blood pressure ≤ 160 mmHg in first 24 hours after intravenous thrombolysis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hemodynamic goal including lower goal of systolic blood pressure | Other | Different hemodynamic goals in different study arms |
|
| Measure | Description | Time Frame |
|---|---|---|
| Modified Rankin Scale score | Fucntional outcome (Modified Rankin Scale) will be assesed by telephone interview. Score from 0 to 6. Higher scores mean a worse outcome. | 90 day after intravenous thrombolysis |
| Mortality rate | At 90 day after intravenous thrombolysis | |
| Rate of symptomatic intracranial hemorrhage | Symptomatic intracranial hemorrhage (sICH) according to SITS-MOST study description of sICH | 24 hours after intravenous thrombolysis |
| Rate of symptomatic intracranial hemorrhage | Symptomatic intracranial hemorrhage (sICH) according to SITS-MOST study description of sICH | 7 days after intravenous thrombolysis |
| Measure | Description | Time Frame |
|---|---|---|
| Change in National Institutes of Health Stroke Scale (NIHSS) | Score form 0 to 42. Higher score indicates worse outcome | at 28 day after intravenous thrombolysis |
| Rate of all Intracranial hemorrhage |
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Inclusion сriteria:
Exclusion criteria:
Сompletion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mikhail Kirov, PhD | Northen state medical university | Study Director |
| Alexey Avidzba | Northen state medical university | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| City Hospital # 1 n.a. E.E. Volosevich | Arkhangelsk | 163000 | Russia |
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| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| D020300 | Intracranial Hemorrhages |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Intracranial hemorrhage will be classified according to Heidelberg bleeding classification
| 24 hours after intravenous thrombolysis |
| Rate of all Intracranial hemorrhage | Intracranial hemorrhage will be classified according to Heidelberg bleeding classification | 7 days after intravenous thrombolysis |
| Lengths of stay in ICU | at 90 day after intravenous thrombolysis |
| Lengths of stay in hospital | at 90 day after intravenous thrombolysis |
| Rate of acute kidney injury | Acute kidney injury will be assesed according to RIFLE Classification | 28 day after intravenous thrombolysis or at discharge |
| D009422 |
| Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |