Hemodynamic in Postreperfusion Period and Functional Recovery in Acute Ischemic Stroke Patients

The Influence of Different Hemodynamic Parameters in First 24 Hours After Intravenous Thrombolysis on Acute Ischemic Stroke Outcomes: a Randomised Clinical Trial

The investigators are suggtesting that lower goals of systolic blood pressure after intravenous thrombolysis may reduce the risk of hemorrhagic complications and improve functional outcomes after acute ischemic stroke.

Inclusion сriteria:

• ischemic stroke diagnosis
• performed intravenous thrombolysis (including "wake up stroke")
• systolic blood pressure >140 mmHg
• informed consent or council of physician agreement

Exclusion criteria:

• absence of informed consent or council of physician agreement
• pregnancy
• patients participainting in other clinical trial in the last 90 days
• any absolute contraindications to intravenous thrombolysis

Сompletion criteria:

• failure to achieve hemodynamic goal for 20 minutes before the start of intravenous thrombolysis
• failure to achieve hemodynamic goal for 60 minutes in first 24 hours after intravenous thrombolysis
• relative arterial hypotension (SBP <100 mmHg for 60 minutes in first 24 hours after intravenous thrombolysis)
• unfavorable effect development (e.g. seizures, angioedema)
• informed consent is retracted