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Retrospective observational study of all patients undergoing aortic root surgery with aortic valve conservation, using the inclusion technique described by Tirone David, between January 1, 2004 and December 31, 2020, at six centers (Nantes - Rennes - Brest - Angers - Tours [two centers]). The main objective of this study is to evaluate the survival without re-intervention for aortic valve dysfunction (surgery or TAVI).
Retrospective observational study of all patients undergoing aortic root surgery with aortic valve conservation, using the inclusion technique described by Tirone David.
Inclusion criteria: Patients undergoing aortic root surgery with conservation of the aortic valve, according to the inclusion technique described by Tirone David, between January 1, 2004 and December 31, 2020, at one of the six centers: Nantes, Rennes, Brest, Angers, Tours (two centers).
Non-inclusion criteria: Prosthetic replacement of the aortic valve intraoperatively during the first operation.
Objectives and endpoints :
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AORTLANTIC registry | Patients undergoing aortic root surgery with aortic valve conservation, using the inclusion technique described by Tirone David, between January 1, 2004 and December 31, 2021, at five centers (Nantes - Rennes - Brest - Angers - Tours University Hospital (UH)) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | There is no intervention in this retrospective study. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the survival without re-intervention for aortic valve dysfunction (surgery or TAVI), after aortic root surgery with conservation of the aortic valve, according to the inclusion technique described by Tirone David | Number of patients alive without re-intervention for aortic valve dysfunction (surgery or TAVI) | Conditional survival starting at 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the overall cardiovascular survival results | Number of patients alive | up to 17 months |
| Evaluate the absence of aortic insufficiency greater than or equal to grade two between the two types of aortic tube graft (right prosthesis or Valsalva prosthesis) |
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Inclusion Criteria:
Non inclusion criteria :
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Patients undergoing aortic root surgery with aortic valve conservation, using the inclusion technique described by Tirone David, between January 1, 2004 and December 31, 2021, at five centers (Nantes, Rennes, Brest, Angers,Tours UH) .
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| Name | Affiliation | Role |
|---|---|---|
| Jean Christian ROUSSEL | Nantes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nantes University Hospital | Nantes | France |
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| ID | Term |
|---|---|
| D000094628 | Aortic Root Aneurysm |
| D001022 | Aortic Valve Insufficiency |
| D000082882 | Bicuspid Aortic Valve Disease |
| ID | Term |
|---|---|
| D017545 | Aortic Aneurysm, Thoracic |
| D001014 | Aortic Aneurysm |
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
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Number of patients alive without aortic insufficiency of grade equal to or greater than two |
| up to 17 months |
| Evaluate the risk of infective endocarditis | Number of patients alive without aortic infective endocarditis | up to 17 months |
| Evaluate the risk of stroke | Number of patients alive without stroke | up to 17 months |
| Evaluate the risk of major bleeding event | Number of patients alive major bleeding event | up to 17 months |
| D002318 |
| Cardiovascular Diseases |
| D001018 | Aortic Diseases |
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |